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<p>RGO-Fe<sub>3</sub>O<sub>4</sub> composite is investigated as prospective options for improving the signal responsiveness of a modified electrode which is able to detect biologically essential molecules like uric acid (UA), a crucial biomarker for gout and kidney stones. A green approach was adopted for the synthesis of this composite using glucose as the green reducing agent. Graphene oxide was reduced to graphene and RGO-Fe<sub>3</sub>O<sub>4</sub> composite was synthesised using a one-pot hydrothermal technique. The result revealed that, as compared to a bare electrode, the fabricated electrode using RGO-Fe<sub>3</sub>O<sub>4</sub> exhibits good electrochemical oxidation of UA. The linear range of working of the RGO-Fe<sub>3</sub>O<sub>4</sub> modified platinum electrode (RGO-Fe<sub>3</sub>O<sub>4</sub>/Pt) is 1 × 10<sup>–6</sup> to 4 × 10<sup>–4</sup>&#xa0;M, with a measured limit of detection of 4.52 × 10<sup>–7</sup>&#xa0;M for UA. Furthermore, the modified electrode was assessed by measuring the concentration of uric acid in artificial samples.</p>

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Glucose mediated one-pot synthesis of RGO-Fe3O4 hybrid composite for electrochemical determination of uric acid

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年4月7日

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  • Arya Sethu Madhavan,
  • Leena Rajith

摘要

RGO-Fe3O4 composite is investigated as prospective options for improving the signal responsiveness of a modified electrode which is able to detect biologically essential molecules like uric acid (UA), a crucial biomarker for gout and kidney stones. A green approach was adopted for the synthesis of this composite using glucose as the green reducing agent. Graphene oxide was reduced to graphene and RGO-Fe3O4 composite was synthesised using a one-pot hydrothermal technique. The result revealed that, as compared to a bare electrode, the fabricated electrode using RGO-Fe3O4 exhibits good electrochemical oxidation of UA. The linear range of working of the RGO-Fe3O4 modified platinum electrode (RGO-Fe3O4/Pt) is 1 × 10–6 to 4 × 10–4 M, with a measured limit of detection of 4.52 × 10–7 M for UA. Furthermore, the modified electrode was assessed by measuring the concentration of uric acid in artificial samples.