<p>Zoonotic diseases like monkeypox (mpox) became the global threat now a day. The diseases primarily spread to the human population through animal-to-human and then human-to-human contact. Mature virions are gathered, shifted to the infected cell’s edge, and then released to infect neighbouring cells and then propagate the infection. Contaminated saliva, respiratory secretions, lesion exudates, crust, patient-used materials, and faeces are all potential routes of monkeypox virus (MPXV) transmission. It is well known that untamed creatures like Gambian rats, sooty mangabeys, and squirrels are crucial in the spread of the MPXV among human populations. The mpox can also be transmitted from mother to child. Among mpox detection methods like genome sequencing, serology, virus isolation and culture, and amplification testing using nucleic acids, a monoclonal antibody is a potentially useful tool for identifying more specifically targeted antibodies. The current strategy for preventing the spread of mpox from person to person focuses on limiting contact with infected patients. The likelihood that humans will get infected with the virus is increased in Ethiopia due to the high rate of human-wild interaction and the movement of animals from the wild into human populations. Therefore, the Ethiopian government needs to focus on research and education as well as the studies that are carried out in the development of vaccines and other treatments. Furthermore, strengthening cooperation between healthcare facilities and academic and research institutions on a national and international level is mandatory. Therefore, the purpose of this review is to focus on mitigation approaches in combating mpox, especially in developing countries.</p>