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<p>The activation of immune Mitogen Activated Protein Kinases (MAPKs) is one of the earliest cellular responses following pathogen attack leading to the phosphorylation of appropriate cytosolic or nuclear targets to regulate cellular processes. In this work, we show that the Arabidopsis nuclear protein DEK2 is a target of MPK6 and regulator of plant defense against bacterial and fungal plant pathogens. Transcriptomic analysis unveils that AtDEK2 modulates transcription of defense-related genes, as well as genes associated with hormone synthesis and signaling. Chromatin immunoprecipitation sequencing (ChIP-Seq) analysis reveals that DEK2 potentially binds to TGGGC(C/T) motifs of ZNF, bZIP, WRKY and TCP transcription factors. DEK2 orchestrates diverse chromatin-related processes. Our findings suggest that DEK2 is recruited to specific chromatin regions by transcription factors and functions as a reader of the bivalent histone mark H3K4me3K27me3.</p>

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The MPK6 target AtDEK2, a chromatin remodeler, modulates transcription of immune-related genes and governs plant immunity

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月12日

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  • Hanna Alhoraibi,
  • Santiago Alejandro-Martinez,
  • David Latrasse,
  • Papita Mandal,
  • Léa Faivre,
  • Xiaoning He,
  • Deborah Manza,
  • Aala A. Abulfaraj,
  • Siba Alharbi,
  • Kiruthiga Mariappan,
  • Olga Artyukh,
  • Fatimah Abdulhakim,
  • Fatimah Aljedaani,
  • Stephan David,
  • Marilia Almeida-Trapp,
  • Jean Bigeard,
  • Delphine Pflieger,
  • Wolfgang Fischle,
  • Stefan T. Arold,
  • Jean Colcombet,
  • Daniel Schubert,
  • Moussa Benhamed,
  • Ikram Blilou,
  • Heribert Hirt,
  • Naganand Rayapuram

摘要

The activation of immune Mitogen Activated Protein Kinases (MAPKs) is one of the earliest cellular responses following pathogen attack leading to the phosphorylation of appropriate cytosolic or nuclear targets to regulate cellular processes. In this work, we show that the Arabidopsis nuclear protein DEK2 is a target of MPK6 and regulator of plant defense against bacterial and fungal plant pathogens. Transcriptomic analysis unveils that AtDEK2 modulates transcription of defense-related genes, as well as genes associated with hormone synthesis and signaling. Chromatin immunoprecipitation sequencing (ChIP-Seq) analysis reveals that DEK2 potentially binds to TGGGC(C/T) motifs of ZNF, bZIP, WRKY and TCP transcription factors. DEK2 orchestrates diverse chromatin-related processes. Our findings suggest that DEK2 is recruited to specific chromatin regions by transcription factors and functions as a reader of the bivalent histone mark H3K4me3K27me3.