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Background <p>Recurrent pre-syncope poses diagnostic challenges, especially when associated with gastroesophageal refluxdisease (GERD) and aspergilloma, as described in this case report of a 27-year-old female.</p> Objective <p>This case report aims to highlight the clinical complexity and diagnostic considerations of recurrent pre-syncope in the presence of coexisting gastrointestinal and respiratory conditions.</p> Case Presentation <p>Despite stable vital signs, she presented with episodes of near-fainting exacerbated by ambulation, accompanied by pleuritic chest pain, visual disturbances, and generalized weakness. Past medical history included GERD and prior aspergilloma treatment. Initial investigations revealed mild electrolyte disturbances and elevated troponin I levels, prompting cardiac evaluation, which was normal. Chest imaging confirmed stable aspergilloma.</p> Discussion <p>The absence of definitive cardiac or neurological pathology emphasized the need to explore alternative and multifactorial mechanisms. While the direct link between GERD, aspergilloma, and syncope remains unclear, the potential for vagal stimulation and chronic respiratory compromise underscores the need for comprehensive evaluation.</p> Conclusion <p>This case report underscores the importance of a broad differential diagnosis, avoidance of premature diagnostic closure, and recognition of non-cardiac contributors to recurrent pre-syncope in young patients. It also highlights the importance of considering multifactorial etiologies in recurrent pre-syncope, urging further research for targeted interventions.</p>

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Recurrent pre-syncope attacks in a young female with GERD and aspergilloma: a case report

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月23日

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  • Saeed M. Alghamdi,
  • Hassan A. Alzahrani,
  • Amal Alsuwayhiri,
  • Nourah AlMubarak,
  • Fayez Almutiri,
  • Ali Almobarki,
  • Nadeen Boubshait

摘要

Background

Recurrent pre-syncope poses diagnostic challenges, especially when associated with gastroesophageal refluxdisease (GERD) and aspergilloma, as described in this case report of a 27-year-old female.

Objective

This case report aims to highlight the clinical complexity and diagnostic considerations of recurrent pre-syncope in the presence of coexisting gastrointestinal and respiratory conditions.

Case Presentation

Despite stable vital signs, she presented with episodes of near-fainting exacerbated by ambulation, accompanied by pleuritic chest pain, visual disturbances, and generalized weakness. Past medical history included GERD and prior aspergilloma treatment. Initial investigations revealed mild electrolyte disturbances and elevated troponin I levels, prompting cardiac evaluation, which was normal. Chest imaging confirmed stable aspergilloma.

Discussion

The absence of definitive cardiac or neurological pathology emphasized the need to explore alternative and multifactorial mechanisms. While the direct link between GERD, aspergilloma, and syncope remains unclear, the potential for vagal stimulation and chronic respiratory compromise underscores the need for comprehensive evaluation.

Conclusion

This case report underscores the importance of a broad differential diagnosis, avoidance of premature diagnostic closure, and recognition of non-cardiac contributors to recurrent pre-syncope in young patients. It also highlights the importance of considering multifactorial etiologies in recurrent pre-syncope, urging further research for targeted interventions.