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Purpose <p>Combination treatments—thermal ablation (TA) and transarterial chemoembolisation (TACE) have been suggested for hepatocellular carcinoma (HCC). After TA a transient hyperemic zone appears around the ablated area, a potential target for TACE. The aim was to determine when this peri-ablational hyperemia is at its widest and most intensely perfused.</p> Materials and methods <p>This prospective study examined the hepatic peri-ablation zones with contrast-enhanced ultrasound (CEUS) in both arterial and portal venous phases, at 0, 2, 6, and 24&#xa0;h after microwave ablation (MWA). Subjects were stratified into two groups, cirrhosis and non-cirrhosis. Quantitative software was used to determine relative tissue perfusion, rendering a hyperemia-to-normal liver (HTNL) ratio. The width of the hyperemic zone was measured on each arterial phase (AP).</p> Results <p>In total, 34 patients (cirrhosis <i>n</i> = 17, non-cirrhosis = 17) were included in this study. The hyperemia was arterially supplied with a HTNL of 567.5% at 0&#xa0;h for the overall group. The AP median HTNL- ratio decrease for the overall group was: –158.9 (2&#xa0;h), -283.8 (6&#xa0;h), and –270.9 (24&#xa0;h) (absolute change in percentage points). No difference was seen between cirrhotic and non-cirrhotic livers. The change in width on the AP for the overall group decreased from 12&#xa0;mm to -2&#xa0;mm (2&#xa0;h), -3&#xa0;mm (6&#xa0;h), and -5&#xa0;mm (24&#xa0;h).</p> Conclusion <p>The peri-ablational hyperemia is arterially supplied and peaks in intensity and width immediately after TA, then declines steeply.</p>

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Quantitative analysis of peri-ablational hyperemia after microwave ablation of liver tumors – exploring the timing for future combination therapies

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月28日

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  • Martin Norström Svensson,
  • Leon Will,
  • Emil Östrand,
  • Hanna Sartor,
  • Bobby Tingstedt,
  • Bodil Andersson,
  • Erik Baubeta

摘要

Purpose

Combination treatments—thermal ablation (TA) and transarterial chemoembolisation (TACE) have been suggested for hepatocellular carcinoma (HCC). After TA a transient hyperemic zone appears around the ablated area, a potential target for TACE. The aim was to determine when this peri-ablational hyperemia is at its widest and most intensely perfused.

Materials and methods

This prospective study examined the hepatic peri-ablation zones with contrast-enhanced ultrasound (CEUS) in both arterial and portal venous phases, at 0, 2, 6, and 24 h after microwave ablation (MWA). Subjects were stratified into two groups, cirrhosis and non-cirrhosis. Quantitative software was used to determine relative tissue perfusion, rendering a hyperemia-to-normal liver (HTNL) ratio. The width of the hyperemic zone was measured on each arterial phase (AP).

Results

In total, 34 patients (cirrhosis n = 17, non-cirrhosis = 17) were included in this study. The hyperemia was arterially supplied with a HTNL of 567.5% at 0 h for the overall group. The AP median HTNL- ratio decrease for the overall group was: –158.9 (2 h), -283.8 (6 h), and –270.9 (24 h) (absolute change in percentage points). No difference was seen between cirrhotic and non-cirrhotic livers. The change in width on the AP for the overall group decreased from 12 mm to -2 mm (2 h), -3 mm (6 h), and -5 mm (24 h).

Conclusion

The peri-ablational hyperemia is arterially supplied and peaks in intensity and width immediately after TA, then declines steeply.