Scholarlink

<p>The rapid industrialisation and agricultural expansion in Nigeria have intensified environmental contamination challenges and created an urgent need for advanced biotechnological interventions in toxicological research. This comprehensive review examines the integration of cutting-edge molecular biotechnology tools, AFLP-PCR, RAPD-PCR, qPCR, and Next-Generation Sequencing (NGS), into the toxicological research landscape of Nigeria. Despite the rich biodiversity and agricultural heritage in Nigeria, positioning it as a potential leader in biotechnology innovation, significant systemic barriers persist. These barriers include inadequate regulatory frameworks, limited research infrastructure, insufficient funding mechanisms, and fragmented policy implementation. The manuscript analyses global advances in molecular biotechnology applications, particularly omics technologies and CRISPR/Cas9 gene editing, and examines the transformative potential for toxicological assessments and environmental monitoring. Key findings reveal that while Nigeria has established foundational institutions such as the Nigerian Toxicology Information Centre and implemented the National Biosafety Management Agency Act, critical gaps remain in advanced molecular technology integration and capacity building. The review proposes a novel trans-disciplinary framework encompassing three strategic pillars: scientific capacity building through international collaborations and specialised training programs, comprehensive policy and regulatory reform incorporating advanced molecular technologies, and sustainable funding mechanisms aligned with the United Nations Sustainable Development Goals. The manuscript concludes that strategic implementation of this integrated framework could position Nigeria as a regional leader in biotechnology-driven environmental solutions while addressing critical public health challenges. The proposed recommendations emphasise balancing innovation with safety, establishing robust regulatory oversight, and fostering public-private partnerships to accelerate biotechnology adoption. This work contributes to the growing body of literature on biotechnology applications in developing countries and provides a roadmap for sustainable biotechnology integration in toxicological research within the Nigerian context. This review not only summarises the state of molecular biotechnology in Nigeria but also proposes a practical roadmap tailored to the country’s institutional, regulatory, and socioeconomic realities.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Integrating advanced molecular biotechnology tools into toxicological research infrastructure for sustainable development in Nigeria

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年1月31日

查看全文
  • Esther P. Oluwamakinde,
  • Oghenefejiro D. Akpofure,
  • Samson O. Adeniran,
  • Olukunle Silas Fagbenro

摘要

The rapid industrialisation and agricultural expansion in Nigeria have intensified environmental contamination challenges and created an urgent need for advanced biotechnological interventions in toxicological research. This comprehensive review examines the integration of cutting-edge molecular biotechnology tools, AFLP-PCR, RAPD-PCR, qPCR, and Next-Generation Sequencing (NGS), into the toxicological research landscape of Nigeria. Despite the rich biodiversity and agricultural heritage in Nigeria, positioning it as a potential leader in biotechnology innovation, significant systemic barriers persist. These barriers include inadequate regulatory frameworks, limited research infrastructure, insufficient funding mechanisms, and fragmented policy implementation. The manuscript analyses global advances in molecular biotechnology applications, particularly omics technologies and CRISPR/Cas9 gene editing, and examines the transformative potential for toxicological assessments and environmental monitoring. Key findings reveal that while Nigeria has established foundational institutions such as the Nigerian Toxicology Information Centre and implemented the National Biosafety Management Agency Act, critical gaps remain in advanced molecular technology integration and capacity building. The review proposes a novel trans-disciplinary framework encompassing three strategic pillars: scientific capacity building through international collaborations and specialised training programs, comprehensive policy and regulatory reform incorporating advanced molecular technologies, and sustainable funding mechanisms aligned with the United Nations Sustainable Development Goals. The manuscript concludes that strategic implementation of this integrated framework could position Nigeria as a regional leader in biotechnology-driven environmental solutions while addressing critical public health challenges. The proposed recommendations emphasise balancing innovation with safety, establishing robust regulatory oversight, and fostering public-private partnerships to accelerate biotechnology adoption. This work contributes to the growing body of literature on biotechnology applications in developing countries and provides a roadmap for sustainable biotechnology integration in toxicological research within the Nigerian context. This review not only summarises the state of molecular biotechnology in Nigeria but also proposes a practical roadmap tailored to the country’s institutional, regulatory, and socioeconomic realities.