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<p>Tubulointerstitial nephritis and uveitis (TINU) syndrome is an uncommon autoimmune disorder. It affects the kidneys and causes eye inflammation. Uveitis in TINU usually presents as bilateral anterior uveitis. The kidney component appears as acute interstitial nephritis. This case study presents the diagnosis of a teenager with both eye and systemic symptoms. Ophthalmologic examination confirmed uveitis. Further investigation then revealed impaired kidney function. Diagnosis was established with a kidney biopsy. This ruled out other systemic diseases. TINU is rare and often not immediately apparent. Clinicians must maintain a high index of suspicion for early recognition and prompt action. Physicians should consider TINU when pediatric patients present with both uveitis and kidney dysfunction. This ensures complete and timely treatment of this complex syndrome.</p>

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Tubulointerstitial nephritis with acute kidney injury and uveitis: a case report in a pediatric patient

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  • 发表日期：

    2026年3月9日

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  • Mugahid Elamin,
  • Wafa Daw,
  • Saeed Alghwery,
  • Reem Mohamed,
  • Nawaf Alhoshan,
  • Abdlmonem Alghamdi

摘要

Tubulointerstitial nephritis and uveitis (TINU) syndrome is an uncommon autoimmune disorder. It affects the kidneys and causes eye inflammation. Uveitis in TINU usually presents as bilateral anterior uveitis. The kidney component appears as acute interstitial nephritis. This case study presents the diagnosis of a teenager with both eye and systemic symptoms. Ophthalmologic examination confirmed uveitis. Further investigation then revealed impaired kidney function. Diagnosis was established with a kidney biopsy. This ruled out other systemic diseases. TINU is rare and often not immediately apparent. Clinicians must maintain a high index of suspicion for early recognition and prompt action. Physicians should consider TINU when pediatric patients present with both uveitis and kidney dysfunction. This ensures complete and timely treatment of this complex syndrome.