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<p>Hyalinizing clear cell carcinoma of lung is rare. In recent years, the increased numbers of case reports and its inclusion in the WHO 2021 classification have led to growing recognition of this tumor. However, it remains unclear whether there are associated underlying conditions, as histological observation around the tumor have not been documented in previous reports. We report a case of a bronchial hyalinizing clear cell carcinoma under suspicion of allergic bronchopulmonary aspergillosis (ABPA). At the distal side of tumor, we found eosinophil-rich mucoid impaction and eosinophilic pneumonia, and also a lesion with intermediate morphology between hyalinizing clear cell carcinoma and basal cells within bronchial inflammatory polyp-like tissue.</p>

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A case report of pulmonary hyalinizing clear cell carcinoma with intermediate-morphology lesion

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月4日

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  • Satoe Numakura,
  • Koji Saito,
  • Yuichi Saito,
  • Shigeki Morita,
  • Yoshikane Yamauchi,
  • Ryo Takeyama,
  • Yasuyuki Kanamoto,
  • Yukinori Sakao

摘要

Hyalinizing clear cell carcinoma of lung is rare. In recent years, the increased numbers of case reports and its inclusion in the WHO 2021 classification have led to growing recognition of this tumor. However, it remains unclear whether there are associated underlying conditions, as histological observation around the tumor have not been documented in previous reports. We report a case of a bronchial hyalinizing clear cell carcinoma under suspicion of allergic bronchopulmonary aspergillosis (ABPA). At the distal side of tumor, we found eosinophil-rich mucoid impaction and eosinophilic pneumonia, and also a lesion with intermediate morphology between hyalinizing clear cell carcinoma and basal cells within bronchial inflammatory polyp-like tissue.