Scholarlink

<p>Chronic hypoxia profoundly impairs male fertility and spermatogenesis. This review synthesizes the mechanisms through which sustained hypoxic exposure degrades semen quality, sperm production, and overall male reproductive function. Evidence indicates that chronic hypoxia directly damages testicular germ cells, reducing sperm count and compromising sperm DNA integrity, apoptosis, and autophagy. It also disrupts the secretion of sex hormones, thereby severely affecting male fertility. In addition, chronic hypoxia-induced oxidative stress is a key factor influencing sperm quality and vitality. Collectively, these findings provide a scientific basis for assessing the risks of chronic hypoxia on male reproductive health and for developing effective therapies to mitigate its impact and safeguard male fertility.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Impact of chronic hypoxia on spermatogenesis

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年10月10日

查看全文
  • Jing Zhu,
  • Yun Cheng,
  • Hong Li,
  • Rong-kai Xie,
  • Hua Hu,
  • Lei Gao

摘要

Chronic hypoxia profoundly impairs male fertility and spermatogenesis. This review synthesizes the mechanisms through which sustained hypoxic exposure degrades semen quality, sperm production, and overall male reproductive function. Evidence indicates that chronic hypoxia directly damages testicular germ cells, reducing sperm count and compromising sperm DNA integrity, apoptosis, and autophagy. It also disrupts the secretion of sex hormones, thereby severely affecting male fertility. In addition, chronic hypoxia-induced oxidative stress is a key factor influencing sperm quality and vitality. Collectively, these findings provide a scientific basis for assessing the risks of chronic hypoxia on male reproductive health and for developing effective therapies to mitigate its impact and safeguard male fertility.