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<p>High-altitude cerebral edema (HACE) is a severe stage of acute mountain sickness (AMS), and if not treated promptly or properly, it can be life-threatening. The pathogenesis of HACE is very complex, encompassing multiple aspects such as overactivation of microglia caused by hypoxia, redox stress, and damage to the blood-brain barrier (BBB). It poses a serious threat to the health of individuals traveling to high-altitude areas. Based on relevant literature, this article reviews the new developments in the research on the pathogenesis of HACE. These research findings contribute to a deeper understanding of the pathogenesis of HACE and provide theoretical support for the prevention, diagnosis, and treatment of HACE.</p>

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Mechanism of formation of high altitude cerebral edema: recent advances

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年7月7日

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  • Shiwang Li,
  • Qiang Zhang,
  • Chunqing Yang,
  • Fei Zhang

摘要

High-altitude cerebral edema (HACE) is a severe stage of acute mountain sickness (AMS), and if not treated promptly or properly, it can be life-threatening. The pathogenesis of HACE is very complex, encompassing multiple aspects such as overactivation of microglia caused by hypoxia, redox stress, and damage to the blood-brain barrier (BBB). It poses a serious threat to the health of individuals traveling to high-altitude areas. Based on relevant literature, this article reviews the new developments in the research on the pathogenesis of HACE. These research findings contribute to a deeper understanding of the pathogenesis of HACE and provide theoretical support for the prevention, diagnosis, and treatment of HACE.