<p>Dental pulp stem cells have significant impact on the development of regenerative medicine, mainly in tissue repair and regeneration. Various studies investigated the reach and application of stem cells in medical fields such as treating bone, nerve injuries, and liver, corneal, and cartilage regeneration. Although there are a great number of studies revealing the potential of stem cells in clinical practice, certain challenges remain. Some of these challenges are choosing the ideal source of stem cells and appropriate cultivation methods. Rapid commercialization of regenerative therapies led to rising number of ethical concerns, and there is a need to establish comprehensive guidelines and standards. Pivotal concerns include the age of a donor and privacy in research. Also, it is vital to create good communication between healthcare providers and regulatory bodies to ensure effective collaboration and communication. Despite success that some studies already presented, negative outcomes and complications from previous therapies based on stem cells highlight the need for better and more rigorous safety protocols. Future research should aim to explain mechanisms that stay behind abnormal tissue growth. With the development of stem cells, there's a demand to establish ethical frameworks and safety guidelines to unlock full therapeutic potential.</p> Graphical Abstract <p></p>