Scholarlink

Background <p>Fibronectin extracellular domain A/B (FN-EDA/B) is a key component of the extracellular matrix (ECM) in the tumor microenvironment (TME). Studies have shown that FN-EDA/B plays multiple roles in tumor development, including promoting tumor cell invasion and metastasis, facilitating immune escape, enhancing tumor angiogenesis, and potentially causing chemoresistance. Despite the substantial volume of published research in this field, a comprehensive perspective is still required to understand the research landscape of FN-EDA/B. Therefore, clarifying the current development status of FN-EDA/B research, identifying its research hotspots, and predicting future trends are crucial for driving scientific progress in this area.</p> Methods <p>We searched for publications spanning from January 2004 to September&#xa0;2024 and ultimately obtained 322 articles after excluding all unqualified literature. We performed bibliometric and visual analysis using the R packages “Bibliometrix,” “VOSviewer,” and “CiteSpace.”</p> Results <p>The number of FN-EDA/B-related articles has increased annually. The United States is the most productive country in this field, followed by Switzerland, and Italy. ETH Zurich, the Swiss Federal Institutes of Technology, and the International Center for Genetic Engineering and Biotechnology are leading in publication output. Notable authors include Neri, Dario; Chauhan, Anil K; and Jon, Sangyong. Keyword cluster analysis revealed that “angiogenesis,” “precision administration,” “biomarker,” and “targeted FN-EDA/B drug immunotherapy and diagnosis” are hotspots in this research field. “Tumor microenvironment” and “receptors” are identified as frontiers for future research.</p> Conclusion <p>This study provides a comprehensive knowledge framework for the study of FN-EDA/B and offers guidance for clinical researchers to understand the current research status and frontiers in this field.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Research trends on the extracellular domain A/B of fibronectin in tumor microenvironment: scientometric and visual analysis

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年5月12日

查看全文
  • Yuan Zhou,
  • Tao Chen,
  • Yawen Pan,
  • Jing Liu

摘要

Background

Fibronectin extracellular domain A/B (FN-EDA/B) is a key component of the extracellular matrix (ECM) in the tumor microenvironment (TME). Studies have shown that FN-EDA/B plays multiple roles in tumor development, including promoting tumor cell invasion and metastasis, facilitating immune escape, enhancing tumor angiogenesis, and potentially causing chemoresistance. Despite the substantial volume of published research in this field, a comprehensive perspective is still required to understand the research landscape of FN-EDA/B. Therefore, clarifying the current development status of FN-EDA/B research, identifying its research hotspots, and predicting future trends are crucial for driving scientific progress in this area.

Methods

We searched for publications spanning from January 2004 to September 2024 and ultimately obtained 322 articles after excluding all unqualified literature. We performed bibliometric and visual analysis using the R packages “Bibliometrix,” “VOSviewer,” and “CiteSpace.”

Results

The number of FN-EDA/B-related articles has increased annually. The United States is the most productive country in this field, followed by Switzerland, and Italy. ETH Zurich, the Swiss Federal Institutes of Technology, and the International Center for Genetic Engineering and Biotechnology are leading in publication output. Notable authors include Neri, Dario; Chauhan, Anil K; and Jon, Sangyong. Keyword cluster analysis revealed that “angiogenesis,” “precision administration,” “biomarker,” and “targeted FN-EDA/B drug immunotherapy and diagnosis” are hotspots in this research field. “Tumor microenvironment” and “receptors” are identified as frontiers for future research.

Conclusion

This study provides a comprehensive knowledge framework for the study of FN-EDA/B and offers guidance for clinical researchers to understand the current research status and frontiers in this field.