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<p>Cortisone was extracted from the adrenal cortex 75&#xa0;years ago. This led to unimagined possibilities in the treatment of inflammatory rheumatic diseases. On the other side of the coin are the severe undesirable effects (side effects) associated with long-term use. More than 40&#xa0;years ago, methotrexate was introduced in rheumatology and soon became the cornerstone in the steroid-sparing treatment; however, the breakthrough in treatment came with the development of biologics at the turn of the millennium. Glucocorticoids currently continue to play a&#xa0;central role in the induction of remission in most inflammatory rheumatic diseases but the importance in maintaining remission has greatly diminished. Glucocorticoids (GC) still play an important role in the treatment of giant cell arteritis (GCA) and polymyalgia rheumatica (PMR). The extensive studies over the past 15&#xa0;years on interleukin‑6 inhibition with tocilizumab in GCA have provided interesting insights into the effects of GCs.</p>

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Bedeutung der Glukokortikoide bei der Therapie entzündlich-rheumatischer Erkrankungen

  • 期刊论文

  • 发表日期：

    2026年3月20日

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  • Peter Villiger

摘要

Cortisone was extracted from the adrenal cortex 75 years ago. This led to unimagined possibilities in the treatment of inflammatory rheumatic diseases. On the other side of the coin are the severe undesirable effects (side effects) associated with long-term use. More than 40 years ago, methotrexate was introduced in rheumatology and soon became the cornerstone in the steroid-sparing treatment; however, the breakthrough in treatment came with the development of biologics at the turn of the millennium. Glucocorticoids currently continue to play a central role in the induction of remission in most inflammatory rheumatic diseases but the importance in maintaining remission has greatly diminished. Glucocorticoids (GC) still play an important role in the treatment of giant cell arteritis (GCA) and polymyalgia rheumatica (PMR). The extensive studies over the past 15 years on interleukin‑6 inhibition with tocilizumab in GCA have provided interesting insights into the effects of GCs.