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<p>Rheumatic diseases such as rheumatoid arthritis (RA), spondyloarthritis (SpA), and systemic lupus erythematosus (SLE) are characterized by dysregulated immune responses and persistent inflammatory processes that lead to progressive tissue damage. The pathogenesis of these conditions is multifactorial and results from a&#xa0;complex interplay of genetic predisposition, environmental factors, and immunological dysregulation. Increasing evidence highlights the central role of the intestinal microbiota and the gut barrier in disease development. Consequently, modification of the intestinal microbiota is gaining attention as a&#xa0;potential therapeutic approach. Nutritional strategies, particularly a&#xa0;fiber-rich diet, may have immunomodulatory effects by promoting beneficial commensal bacteria and increasing the production of short-chain fatty acids (SCFAs). SCFAs, especially butyrate, stabilize the integrity of the gut barrier and have anti-inflammatory properties by inducing regulatory T cells (Tregs) and dampening proinflammatory immune responses. Thus, targeted modulation of the microbiome through nutritional interventions represents a&#xa0;promising addition to established therapeutic concepts for rheumatic diseases.</p>

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Mikrobiom, Ernährung und Rheuma

  • 期刊论文

  • 发表日期：

    2026年1月27日

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  • Christina Heidt,
  • Martin A. Kriegel

摘要

Rheumatic diseases such as rheumatoid arthritis (RA), spondyloarthritis (SpA), and systemic lupus erythematosus (SLE) are characterized by dysregulated immune responses and persistent inflammatory processes that lead to progressive tissue damage. The pathogenesis of these conditions is multifactorial and results from a complex interplay of genetic predisposition, environmental factors, and immunological dysregulation. Increasing evidence highlights the central role of the intestinal microbiota and the gut barrier in disease development. Consequently, modification of the intestinal microbiota is gaining attention as a potential therapeutic approach. Nutritional strategies, particularly a fiber-rich diet, may have immunomodulatory effects by promoting beneficial commensal bacteria and increasing the production of short-chain fatty acids (SCFAs). SCFAs, especially butyrate, stabilize the integrity of the gut barrier and have anti-inflammatory properties by inducing regulatory T cells (Tregs) and dampening proinflammatory immune responses. Thus, targeted modulation of the microbiome through nutritional interventions represents a promising addition to established therapeutic concepts for rheumatic diseases.