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<p>Here, we report a case of TP53-mutated acute myeloid leukemia (AML) with monocytic differentiation that showed striking histiocytoid morphologic transformation following induction chemotherapy. Post-treatment blasts demonstrated significant morphologic overlap with mature malignant histiocytic neoplasms, particularly histiocytic sarcoma&#xa0;subtype, creating a potential diagnostic pitfall. Retained myeloperoxidase expression, together with the absence of cyclin&#xa0;D1 expression, supported&#xa0;a&#xa0;diagnosis of persistent AML rather than divergent histiocytic differentiation.</p>

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Myeloid-lineage blasts with histiocytoid differentiation in TP53 mutated acute myeloid leukemia: a deceptive morphologic overlap with mature malignant histiocytic neoplasms

  • 期刊论文

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  • 发表日期：

    2026年8月3日

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  • Neha Seth,
  • Aishwarya Ravindran

摘要

Here, we report a case of TP53-mutated acute myeloid leukemia (AML) with monocytic differentiation that showed striking histiocytoid morphologic transformation following induction chemotherapy. Post-treatment blasts demonstrated significant morphologic overlap with mature malignant histiocytic neoplasms, particularly histiocytic sarcoma subtype, creating a potential diagnostic pitfall. Retained myeloperoxidase expression, together with the absence of cyclin D1 expression, supported a diagnosis of persistent AML rather than divergent histiocytic differentiation.