Background <p>Due to demographic change, the age structure of general practitioners, and the shortage of physicians, general practices will face a&#xa0;variety of challenges in the coming years. These challenges include a&#xa0;high workload and the specific health-related care needs of chronically ill and multimorbid patients. Advanced practice nurses (APN) could help address these challenges.</p> Objective <p>This study examines the experiences of general practitioners in rural areas with the use of APN for chronically ill and multimorbid patients.</p> Materials and methods <p>One APN was deployed in each of nine general practices in rural areas of Rhineland–Palatinate. After a&#xa0;period of approximately 2.5&#xa0;years, ten guided telephone interviews were conducted with the practice owners. The evaluation was based on the qualitative content analysis according to Mayring and Fenzl.</p> Results <p>General practitioners reported that the APN relieved their workload and that the patients were very satisfied. However, a&#xa0;legal framework and a&#xa0;financing strategy were lacking to firmly integrate the APN profession into the healthcare system.</p> Conclusion <p>Experiences with APN are predominantly positive. Implementation hurdles are primarily encountered outside of the practitioners’ own practices.</p>