<p>Cardiovascular disease (CVD) represents a major global public health burden. Traditional research models struggle to meet the demands of elucidating disease mechanisms and advancing drug development due to limitations such as species differences. Cardiac organoids, with their high physiological fidelity, have emerged as alternative models. Cardiac organoids demonstrate unique value in modeling various diseases such as myocardial infarction, heart failure, and cardiomyopathy, and are widely applied in drug toxicity assessment and regenerative medicine research. The integration of artificial intelligence technology with cardiac organoids has enabled intelligent upgrades in organoid construction optimization and multidimensional monitoring analysis, significantly enhancing research efficiency and precision. This review summarizes the application progress of cardiac organoids in CVD research, outlining their developmental prospects in precision medicine and drug discovery.</p> Graphical Abstract <p></p>