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<p>Gliomas, accounting for approximately 30% of central nervous system tumors, are the most common malignant brain tumors, with glioblastoma being the most lethal. Current treatments, including surgery, chemotherapy, and radiotherapy, are often limited by tumor aggression and drug resistance. Photodynamic therapy (PDT) has emerged as a promising approach, utilizing photosensitizers activated by specific light wavelengths to generate reactive oxygen species that selectively target tumor cells, damage tumor vasculature, and activate antitumor immunity. Compared to conventional therapies, PDT offers improved patient tolerance and fewer systemic side effects. This review explores PDT’s mechanisms, clinical applications, and combination strategies with chemotherapy, nanomaterials, immunotherapy, and metaverse technology for glioma treatment. Clinical studies demonstrate PDT’s efficacy in improving resection rates and survival outcomes, particularly for high-grade and recurrent gliomas. Future research should optimize photosensitizer selectivity, enhance delivery via nanotechnology, and validate PDT’s efficacy across glioma types to establish it as a cornerstone of glioma therapy.</p> Graphical Abstract <p></p>

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Application and prospects of photodynamic therapy in the treatment of brain glioma

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年12月22日

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  • Fei Yang,
  • Longgang Zhou,
  • Xiuwei Yan,
  • Shaoshan Hu

摘要

Gliomas, accounting for approximately 30% of central nervous system tumors, are the most common malignant brain tumors, with glioblastoma being the most lethal. Current treatments, including surgery, chemotherapy, and radiotherapy, are often limited by tumor aggression and drug resistance. Photodynamic therapy (PDT) has emerged as a promising approach, utilizing photosensitizers activated by specific light wavelengths to generate reactive oxygen species that selectively target tumor cells, damage tumor vasculature, and activate antitumor immunity. Compared to conventional therapies, PDT offers improved patient tolerance and fewer systemic side effects. This review explores PDT’s mechanisms, clinical applications, and combination strategies with chemotherapy, nanomaterials, immunotherapy, and metaverse technology for glioma treatment. Clinical studies demonstrate PDT’s efficacy in improving resection rates and survival outcomes, particularly for high-grade and recurrent gliomas. Future research should optimize photosensitizer selectivity, enhance delivery via nanotechnology, and validate PDT’s efficacy across glioma types to establish it as a cornerstone of glioma therapy.

Graphical Abstract