<p>Integrated Academic Health Systems (IAHS) represent partnerships between healthcare providers, academic institutions, and research centers to improve healthcare delivery through knowledge integration. Research capacity building (RCB) is essential for IAHS to achieve their mission, yet many systems lack a structured, scalable approach to support it. We present a conceptual framework for enhancing research capacity in IAHS using an adapted version of Cooke’s RCB model, integrating information technology (IT) as a foundational driver. Cooke’s six-principle framework was used as a guiding model and modified by embedding specific IT strategies within each domain. The framework outlines multilevel activities (individual, team, organizational, and supra-organizational) to support skill-building, impactful research, collaboration, dissemination, sustainability, and infrastructure. The proposed IT-driven framework highlights the role of digital tools such as learning management systems, interoperable electronic health records, virtual collaboration platforms, and data analytics systems in strengthening research capabilities. These tools address recognised barriers to RCB, such as skill gaps, fragmented systems, and limited dissemination infrastructure. The framework also suggests IT-based indicators for monitoring progress and impact. By aligning IT infrastructure with research capacity goals, IAHS can adopt more sustainable, collaborative, and practice-relevant research environments. This conceptual model offers a strategic blueprint for institutions seeking to structure and scale research capacity in complex academic–clinical ecosystems.</p>