Background <p>Nursing is a practice-based profession, with clinical practice at the heart of nursing education. As preregistering education is to ensure that nursing students can satisfy the quality and safety standards set for patient care. Unsafe student practice is defined as behavior that puts the patient or staff in physical or emotional harm. Despite the recognized importance of clinical training in nursing education, limited research has examined how regional differences within Egypt influence the quality of practical training and student safety. This study addresses this gap by assessing the impact of institute region on students’ performance and educational outcomes, offering valuable insights for policymakers and educators to tailor interventions that enhance nursing education across different regions.</p> Objective <p>To evaluate the factors that influence the quality of practical nursing education among students in technical nursing institutes of the Ministry of Health in Alexandria during the academic years 2019–2020.</p> Setting <p>The study was carried out at of six technical nursing institutes in Alexandria, Egypt.</p> Methods <p>This study A cross-sectional survey was conducted at six technical nursing institutes under the Ministry of Health in Alexandria: Al Jumhuriya, Al-Amriya, Ras El Teen, Abu Qir, Burj Al Arab, and Dar Ismail. A cross-sectional survey design was employed to identify factors affecting the quality of nursing education among students enrolled during the 2019-2020 academic year. The sample included a total of 260 students, with 142 students in the second grade and 118 students in the third grade. </p> Results <p>The multivariate logistic regression analysis identified significant predictors of achieving a high total score among nursing students from the Wasat region had a markedly higher likelihood of attaining a high score, with an adjusted odds ratio (OR) of 8.86 (95% Confidence Interval [CI]: 4.09 to 19.20). Similarly, students from the Sharq region also showed a higher probability, with an OR of 7.57 (95% CI: 3.29 to 17.36). These findings indicate that regional differences significantly influence student performance, with students from Wasat and Sharq being much more likely to achieve high scores compared to other regions Conclusion: Effective teaching methods are essential for the future of general nursing education, to develop the necessary skills and competence required for their professional success. </p> Conclusion <p>Effective teaching methods are essential for the future of general nursing education, to develop the necessary skills and competence required for their professional success. </p> Recommendations <p>Implementing targeted simulation-based training programs, strengthening infrastructure, and fostering collaboration between educational and clinical institutions. </p>