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<p>This article is an extended review which arises from the ARTERY Career Development Lecture Award 2025 (Valencia, Spain) and reflects my scientific trajectory as a clinical academic pharmacist working at the interface of vascular physiology, pharmacology, and translational hypertension research. Beginning with my early mechanistic studies of sodium and fluid homeostasis during my PhD, this body of work has sought to understand how the events underlying the measurable biological signals contribute to vascular injury beyond BP alone. Subsequent translational and population-level investigations have focused on quantifying pressure-independent modulation of arterial stiffness and redefining antihypertensive “class effects” on the arterial wall.</p>

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One Size Does Not Fit All: From Blood Pressure Reduction to Personalised Modulation of Arterial Stiffness in Hypertension—An Extended Review Resulting From the ARTERY Career Development Lecture Award 2025

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  • 出版模式：

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  • 发表日期：

    2026年5月28日

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  • Ryan J. McNally

摘要

This article is an extended review which arises from the ARTERY Career Development Lecture Award 2025 (Valencia, Spain) and reflects my scientific trajectory as a clinical academic pharmacist working at the interface of vascular physiology, pharmacology, and translational hypertension research. Beginning with my early mechanistic studies of sodium and fluid homeostasis during my PhD, this body of work has sought to understand how the events underlying the measurable biological signals contribute to vascular injury beyond BP alone. Subsequent translational and population-level investigations have focused on quantifying pressure-independent modulation of arterial stiffness and redefining antihypertensive “class effects” on the arterial wall.