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Background <p>Intracranial aneurysms (IAs) are vascular abnormalities characterized by localized dilation of cerebral arteries, with a higher prevalence in females. Ruptured IAs can lead to subarachnoid hemorrhage, a life-threatening condition. The purpose of this study is to investigate gender-based differences in aneurysm distribution and rupture risk, focusing on the role of anatomical, hemodynamic, and hormonal factors.</p> Results <p>Among 164 patients, 85 were women (51.83%) and 79 were men (48.17%). The anterior communicating artery (ACA) was the most common site (34.76%), followed by the internal carotid artery (ICA) (30.49%) and middle cerebral artery (MCA) (18.29%). Women had a higher prevalence of ICA aneurysms (25.91% vs. 24.09%), while men showed a greater occurrence in the ACA (27.46% vs. 29.54%). Age-related differences were observed, with women experiencing ruptures at older ages.</p> Conclusions <p>Gender disparities in IA distribution highlight the influence of anatomical and hormonal factors. Women exhibit a higher prevalence in ICA aneurysms, whereas men are more affected in the ACA. These findings emphasize the need for sex-specific risk assessment, preventive strategies, and tailored clinical management. Future research should focus on predictive modeling for improved early detection and intervention.</p>

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Gender-Based Patterns in Intracranial Aneurysm Site and Rupture Risk: A Single-Center Retrospective Cohort Study from the Caucasus region

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月22日

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  • A.’sem Mohammad Abedalqader Qannas,
  • Abdul Azim Abdul Haffis,
  • Ahmed Abdelkader,
  • Erekle Ekvtimishvili,
  • Jui Gaikwad,
  • Teimurazi Tchikhoria,
  • Alan Stephan John,
  • Maryam Abubakar,
  • Gargi Gautam,
  • Rajvi Soni,
  • Nazia Mohammad,
  • Ahmad Hammoud,
  • Ryan George Rajeev,
  • Chetali Patil

摘要

Background

Intracranial aneurysms (IAs) are vascular abnormalities characterized by localized dilation of cerebral arteries, with a higher prevalence in females. Ruptured IAs can lead to subarachnoid hemorrhage, a life-threatening condition. The purpose of this study is to investigate gender-based differences in aneurysm distribution and rupture risk, focusing on the role of anatomical, hemodynamic, and hormonal factors.

Results

Among 164 patients, 85 were women (51.83%) and 79 were men (48.17%). The anterior communicating artery (ACA) was the most common site (34.76%), followed by the internal carotid artery (ICA) (30.49%) and middle cerebral artery (MCA) (18.29%). Women had a higher prevalence of ICA aneurysms (25.91% vs. 24.09%), while men showed a greater occurrence in the ACA (27.46% vs. 29.54%). Age-related differences were observed, with women experiencing ruptures at older ages.

Conclusions

Gender disparities in IA distribution highlight the influence of anatomical and hormonal factors. Women exhibit a higher prevalence in ICA aneurysms, whereas men are more affected in the ACA. These findings emphasize the need for sex-specific risk assessment, preventive strategies, and tailored clinical management. Future research should focus on predictive modeling for improved early detection and intervention.