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Background <p>Arterial stiffness is a critical determinant of cardiovascular risk and is influenced by various metabolic factors. The triglyceride-glucose (TyG) index, an emerging marker of insulin resistance, and visceral adiposity are both associated with arterial stiffness. However, the interaction between TyG index and visceral adiposity in relation to arterial stiffness has not been thoroughly explored.</p> Methods <p>A total of 761 participants underwent health examinations, including measurements of fasting blood glucose, lipid profiles, visceral fat area (VFA), and arterial stiffness assessed by brachial-ankle pulse wave velocity (baPWV). Participants were stratified by TyG index and VFA. Logistics regression and interaction analyses were conducted to assess the combined effect of TyG and VFA on arterial stiffness.</p> Results <p>Both the high TyG index and high VFA were independently associated with arterial stiffness(OR, 3.786, 95% CI 2.383, 6.014, <i>p</i>&lt;0.001; OR, 4.689, 95% CI 2.770, 7.940, <i>p</i> &lt;0.001, respectively). A significant interaction between TyG index and VFA on arterial stiffness was found (p for interaction &lt;0.001), with a relative excess risk due to interaction (RERI) of -10.410 (95% CI -11.746, -9.074), an attributable proportion due to interaction (AP) of -1.474 (95% CI -1.644,-1.284), and an synergy index (SI) of 0.118 (95% CI 0.105, 0.131).</p> Conclusions <p>The TyG index interacts with VFA on arterial stiffness. This interaction highlights the importance of considering both markers in risk assessment of arterial stiffness and prevention strategies aimed at improving vascular health.</p>

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The Interaction Between Triglyceride–Glucose Index and Visceral Adiposity in Arterial Stiffness

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月1日

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  • Guoyu Wang,
  • Chuanmeng Zhang,
  • Suyun Jiang,
  • Qingqing Zhang,
  • Peng Gao,
  • Hong Xu,
  • Jing Zheng,
  • Si Sun,
  • Jingyuan Cao,
  • Li Zhu

摘要

Background

Arterial stiffness is a critical determinant of cardiovascular risk and is influenced by various metabolic factors. The triglyceride-glucose (TyG) index, an emerging marker of insulin resistance, and visceral adiposity are both associated with arterial stiffness. However, the interaction between TyG index and visceral adiposity in relation to arterial stiffness has not been thoroughly explored.

Methods

A total of 761 participants underwent health examinations, including measurements of fasting blood glucose, lipid profiles, visceral fat area (VFA), and arterial stiffness assessed by brachial-ankle pulse wave velocity (baPWV). Participants were stratified by TyG index and VFA. Logistics regression and interaction analyses were conducted to assess the combined effect of TyG and VFA on arterial stiffness.

Results

Both the high TyG index and high VFA were independently associated with arterial stiffness(OR, 3.786, 95% CI 2.383, 6.014, p<0.001; OR, 4.689, 95% CI 2.770, 7.940, p <0.001, respectively). A significant interaction between TyG index and VFA on arterial stiffness was found (p for interaction <0.001), with a relative excess risk due to interaction (RERI) of -10.410 (95% CI -11.746, -9.074), an attributable proportion due to interaction (AP) of -1.474 (95% CI -1.644,-1.284), and an synergy index (SI) of 0.118 (95% CI 0.105, 0.131).

Conclusions

The TyG index interacts with VFA on arterial stiffness. This interaction highlights the importance of considering both markers in risk assessment of arterial stiffness and prevention strategies aimed at improving vascular health.