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<p>Thoracic aortic aneurysm (TAA) refers to the abnormal dilation of the thoracic aorta above the diaphragm, and dyslipidemia has been implicated in increasing the risk of its development. The emergence of lipidomics technology has deepened our understanding of this disease. In this study, we utilized Mendelian randomization analysis (MR) to elucidate the causal relationship between TAA and plasma lipidome. We found a strong correlation between increased levels of phosphatidylethanolamine (18:0_18:2) in the blood and occurrence of TAA. Our research also revealed that TAA may lead to a decrease in levels of phosphatidylcholine (16:0_18:3), phosphatidylcholine (18:2_20:4), and phosphatidylcholine (O − 17:0_17:1) in the plasma. Through genetic techniques, our study has shed light on the close relationship between TAA and plasma lipidome, providing direction for future clinical research.</p>

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The Causal Relationship Between Thoracic Aortic Aneurysm and Plasma Lipidome: A Mendelian Randomization Study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月9日

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  • Guangtao Liu,
  • Yi Xu,
  • Sha Pan,
  • Mincai Li,
  • Hongli Xia,
  • Ansen Wu,
  • Guoli Liu

摘要

Thoracic aortic aneurysm (TAA) refers to the abnormal dilation of the thoracic aorta above the diaphragm, and dyslipidemia has been implicated in increasing the risk of its development. The emergence of lipidomics technology has deepened our understanding of this disease. In this study, we utilized Mendelian randomization analysis (MR) to elucidate the causal relationship between TAA and plasma lipidome. We found a strong correlation between increased levels of phosphatidylethanolamine (18:0_18:2) in the blood and occurrence of TAA. Our research also revealed that TAA may lead to a decrease in levels of phosphatidylcholine (16:0_18:3), phosphatidylcholine (18:2_20:4), and phosphatidylcholine (O − 17:0_17:1) in the plasma. Through genetic techniques, our study has shed light on the close relationship between TAA and plasma lipidome, providing direction for future clinical research.