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Introduction <p>In Mexico, 25–45% of medical students experience burnout syndrome, which may be reduced through mindfulness-based interventions (MBI). No study has evaluated this intervention’s impact on our country’s population. Therefore, this study aimed to determine the effects of an eight-week MBI on medical students, professors and administrative staff from the Faculty of Medicine at the National Autonomous University of Mexico (UNAM), Mexico.</p> Methods <p>An exploratory pilot quasi-experimental study incorporating pre- and post-tests was implemented with 38 participants. The Mindfulness-Based Stress Reduction (MBSR) program was conducted over 8 weeks to evaluate its efficacy on the evolution on psychological, biological, and neurophysiological parameters. Data was analyzed using either the paired Student’s t-test or the Wilcoxon test.</p> Results <p>This study recruited 38 participants with a mean age of 28 years, 84% of whom were women. 24% of the cohort were first-year students, and over half attended all sessions. The intervention yielded significant effects on reduction in cortisol levels (<i>p</i> &lt; 0.001) and in the dimensions of emotional exhaustion (EE, <i>p</i> &lt; 0.001) and depersonalization (DP, <i>p</i> = 0.008), and an increase in the sense of personal accomplishment (PA, <i>p</i> &lt; 0.001)—as well as on P300 amplitude (<i>p</i> = 0.032).</p> Discussion <p>The findings indicated that mindfulness-based intervention suggests a positive effect on burnout syndrome, cortisol levels, and influences neurophysiological metrics such as the P300 amplitude. Future studies should be conducted in more controlled trials with a larger, more homogeneous sample to ensure the replicability of these data and explore their long-term effects.</p>

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Pilot study: mindfulness-based intervention reduces burnout syndrome and associated biomarkers in a Mexican university population

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月8日

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  • Mireya Velázquez-Paniagua,
  • Laura Gómez-Virgilio,
  • Blanca Margarita Gómez-Chavarín,
  • Maria-del-Carmen Cárdenas-Aguayo,
  • Raúl Sampieri-Cabrera

摘要

Introduction

In Mexico, 25–45% of medical students experience burnout syndrome, which may be reduced through mindfulness-based interventions (MBI). No study has evaluated this intervention’s impact on our country’s population. Therefore, this study aimed to determine the effects of an eight-week MBI on medical students, professors and administrative staff from the Faculty of Medicine at the National Autonomous University of Mexico (UNAM), Mexico.

Methods

An exploratory pilot quasi-experimental study incorporating pre- and post-tests was implemented with 38 participants. The Mindfulness-Based Stress Reduction (MBSR) program was conducted over 8 weeks to evaluate its efficacy on the evolution on psychological, biological, and neurophysiological parameters. Data was analyzed using either the paired Student’s t-test or the Wilcoxon test.

Results

This study recruited 38 participants with a mean age of 28 years, 84% of whom were women. 24% of the cohort were first-year students, and over half attended all sessions. The intervention yielded significant effects on reduction in cortisol levels (p < 0.001) and in the dimensions of emotional exhaustion (EE, p < 0.001) and depersonalization (DP, p = 0.008), and an increase in the sense of personal accomplishment (PA, p < 0.001)—as well as on P300 amplitude (p = 0.032).

Discussion

The findings indicated that mindfulness-based intervention suggests a positive effect on burnout syndrome, cortisol levels, and influences neurophysiological metrics such as the P300 amplitude. Future studies should be conducted in more controlled trials with a larger, more homogeneous sample to ensure the replicability of these data and explore their long-term effects.