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Background <p>Metabolic dysfunction-associated steatosis liver disease (MASLD) is a chronic liver disease that occurs when fat builds up in the liver. It is linked to other diseases such as metabolic syndrome, obesity, type 2 diabetes, cardiovascular disease, and hypertension. Since there is no FDA-approved drug for targeting early-stage MASLD, certain conventional drugs used to suppress it are associated with numerous side effects. Resmetirom’s a selective thyroid hormone receptor-β (THR‐β) agonist, which is a recent FDA-approved drugs offer promising advancements by targeting liver fat metabolism which have shown its effects on later-stage of MASLD. Essential oils (EOs), extracted from a variety of herbs and spices, have drawn interest due to their high content of active compounds and potential function to support liver health. A comprehensive literature survey was conducted using major online databases including PubMed, Scopus, and Google Scholar using combinations of keywords such as essential oil, spice, herb, MASLD, oxidative stress, and inflammation.</p> Major findings <p>Essential oils from ginger, turmeric, and citrus can attenuate hepatic lipid accumulation, regulate key metabolic pathways including PPAR-α, SREBP-1c, reduce oxidative stress and inflammatory signalling. Linalool, D-limonene, zingiberene, and other phytoconstituents found in EOs have the potential to be useful components for reducing MASLD through lipid-modulating, anti-inflammatory, and antioxidant mechanisms.</p> Conclusion <p>The current evidence on the benefits of EOs as a functional ingredient in neutralizing MASLD is rather limited, future investigation with well- designed methodologies is utmost required to validate preclinical findings, optimize dosing regimens, determine long-term safety and efficacy in humans. Further research is required to enhance the specific mechanism and formulation for developing EOs into beneficial therapeutics strategies for MASLD. The review focus on tabulating different essential oils as functional ingredients that are extracted from different herbs and spices as these oils contain active phytoconstituents that showed promising results in the ameliorating MASLD.</p> Graphical Abstract <p></p>

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Essential oils from spices and herbs as a functional ingredient for mitigating metabolic dysfunction-associated steatosis liver disease (MASLD)

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月7日

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  • Manashi Karmakar,
  • Binita Chakraborty,
  • Punam Kumari,
  • Pervej Alom Barbhuiya,
  • Sunandan Baruah,
  • Manash Pratim Sarma,
  • Srijita Chakrabarti,
  • Manash Pratim Pathak

摘要

Background

Metabolic dysfunction-associated steatosis liver disease (MASLD) is a chronic liver disease that occurs when fat builds up in the liver. It is linked to other diseases such as metabolic syndrome, obesity, type 2 diabetes, cardiovascular disease, and hypertension. Since there is no FDA-approved drug for targeting early-stage MASLD, certain conventional drugs used to suppress it are associated with numerous side effects. Resmetirom’s a selective thyroid hormone receptor-β (THR‐β) agonist, which is a recent FDA-approved drugs offer promising advancements by targeting liver fat metabolism which have shown its effects on later-stage of MASLD. Essential oils (EOs), extracted from a variety of herbs and spices, have drawn interest due to their high content of active compounds and potential function to support liver health. A comprehensive literature survey was conducted using major online databases including PubMed, Scopus, and Google Scholar using combinations of keywords such as essential oil, spice, herb, MASLD, oxidative stress, and inflammation.

Major findings

Essential oils from ginger, turmeric, and citrus can attenuate hepatic lipid accumulation, regulate key metabolic pathways including PPAR-α, SREBP-1c, reduce oxidative stress and inflammatory signalling. Linalool, D-limonene, zingiberene, and other phytoconstituents found in EOs have the potential to be useful components for reducing MASLD through lipid-modulating, anti-inflammatory, and antioxidant mechanisms.

Conclusion

The current evidence on the benefits of EOs as a functional ingredient in neutralizing MASLD is rather limited, future investigation with well- designed methodologies is utmost required to validate preclinical findings, optimize dosing regimens, determine long-term safety and efficacy in humans. Further research is required to enhance the specific mechanism and formulation for developing EOs into beneficial therapeutics strategies for MASLD. The review focus on tabulating different essential oils as functional ingredients that are extracted from different herbs and spices as these oils contain active phytoconstituents that showed promising results in the ameliorating MASLD.

Graphical Abstract