Abstract <p>Culturally competent communication is important for minimizing disparities in healthcare access and quality and is a focus of undergraduate medical education. The Eastern Association for the Surgery of Trauma has partnered with communication experts to offer a virtual communication course to medical students from the United States and Saudi Arabia. The course, now in its sixth year, is presented in five weekly modules using Zoom technology. Each class focuses on a unique communication skill and involves one hour of skills practice with actors, facilitated by a physician. We conducted, recorded, and transcribed three focus groups to elicit students’ reflections on the class and the impact on their patient-centered communication. Twenty-four students and 10 faculty from 17 medical schools in Saudi Arabia and the US participated, supported by 19 actors. Twelve students (both Saudi and US-based) participated in the focus groups. Broad themes identified in data analysis included communication skills, cultural competency, and professionalism. Participants reported improved patient-centered communication confidence and reflected on the influence of cultural context in gender roles and family authority. Students appreciated the clinical relevance of classroom knowledge in practice. This international communication course prepared students to respond respectfully and sensitively to patients from diverse cultures and exposed medical students to varied cultural expectations and practices. Students completing the course reported increased self-confidence executing important patient-centered medical interviews, appreciated the opportunity to apply concepts learned in classrooms, and demonstrated positive attributes of medical professionalism when participating in class.</p>