<p>Glioblastoma (GBM) is a very aggressive and invasive brain tumor that is difficult to treat due to its genetic variation, resistance to conventional treatment, and high recurrence. Even though there has been a great advancement in surgical, chemotherapy, and radiotherapy treatments, the poor prognosis for patients and low survival rates remain unchanged. Boron Neutron Capture Therapy (BNCT) is a new targeted treatment that offers precision with maximum efficacy while minimizing invasiveness. Through this process, the selective release of boron into the tumor cells was distributed to the tumor site. This review article discusses the mechanism of BNCT and its advantages and disadvantages, clinical research on BNCT in GBM patients, and their future aspects to manage glioblastoma. Overall, the review critically evaluates its reliability problems and future possibilities, emphasizing its potential to transform treatment results for this life-threatening condition.</p>