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Purpose <p>With the continuous improvement and maturity of the technology for constructing organ models of head and neck tumors in recent years, novel three-dimensional models represented by patient-derived organoids (PDOs) have been used in the research of various tumors. To systematically elucidate the current research progress and application directions of head and neck tumor organoids, we performed the systematic review.</p> Methods <p>Using "head and neck, cancer or tumor, organoid or organoids" as search terms, relevant articles published before November 2023 were retrieved and systematically summarized and analyzed from the China National Knowledge Infrastructure (CNKI), Wanfang Database, and PubMed.</p> Results <p>The novel three-dimensional models represented by tumor organoids have filled the gaps in spatial structure and clinical reproducibility of traditional two-dimensional cancer cell lines. They have been widely used in the research of head and neck cancer (HNC). The use of co-culture technology and the air–liquid interface method has preliminarily achieved the construction of the tumor microenvironment in PDO models, while the development of new technologies such as microfluidic devices, organ chips, and organoid assemblies allows for a more realistic reproduction of tumor structure and environment in vitro, with broad application prospects.</p> Conclusion <p>Head and neck PDO models have been widely used in basic research and personalized medicine. Lowering the construction cost, improving the predictive accuracy of models, and exploring the mechanisms of tumor development and metastasis may be directions for further research in the future.</p>

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The techniques and applications of patient-derived head and neck cancer organoids: a systematic review

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年3月31日

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  • Yangyang Xia,
  • Shang Xie,
  • Zhigang Cai,
  • Xiaofeng Shan

摘要

Purpose

With the continuous improvement and maturity of the technology for constructing organ models of head and neck tumors in recent years, novel three-dimensional models represented by patient-derived organoids (PDOs) have been used in the research of various tumors. To systematically elucidate the current research progress and application directions of head and neck tumor organoids, we performed the systematic review.

Methods

Using "head and neck, cancer or tumor, organoid or organoids" as search terms, relevant articles published before November 2023 were retrieved and systematically summarized and analyzed from the China National Knowledge Infrastructure (CNKI), Wanfang Database, and PubMed.

Results

The novel three-dimensional models represented by tumor organoids have filled the gaps in spatial structure and clinical reproducibility of traditional two-dimensional cancer cell lines. They have been widely used in the research of head and neck cancer (HNC). The use of co-culture technology and the air–liquid interface method has preliminarily achieved the construction of the tumor microenvironment in PDO models, while the development of new technologies such as microfluidic devices, organ chips, and organoid assemblies allows for a more realistic reproduction of tumor structure and environment in vitro, with broad application prospects.

Conclusion

Head and neck PDO models have been widely used in basic research and personalized medicine. Lowering the construction cost, improving the predictive accuracy of models, and exploring the mechanisms of tumor development and metastasis may be directions for further research in the future.