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<p>Polymeric devices, such as polydimethylsiloxane (PDMS)-based devices, have been extensively used in various biomedical applications, from implantable devices to biosensors. Nevertheless, it is prone to colonization by microorganisms due to its hydrophobic nature, leading to device-associated infections. This study presents a simple polydopamine (PDA) coating on PDMS via dip coating technique, and the effect of coating duration on surface chemistry, stability, and partial broad-spectrum antimicrobial performance. The coatings were characterized using Fourier Transform Infrared (FTIR) spectroscopy, Energy Dispersive X-Ray analysis (EDX), and Scanning Electron Microscope (SEM). The optimum coating time of 12&#xa0;h showed the maximum antimicrobial efficiency of 63.63% and 68.03% antibacterial activity against <i>Staphylococcus aureus</i> and <i>Escherichia coli</i>, respectively. The 12&#xa0;h deposited coatings exhibited 97.33% antifungal activity against <i>Candida albicans</i>. Beyond 12&#xa0;h of coating, the performance deteriorates due to the surface morphology. This work shows that PDA coating duration plays a critical role in promoting antibacterial and antifungal activities for applications in biomedicine and biomedical implants.</p>

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Influence of Coating Duration on Polydopamine Coating Stability, Surface Hydrophobic Recovery, and Antimicrobial Performance for Biomedical Implant Applications

  • 期刊论文

  • 发表日期：

    2026年7月22日

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  • Ritika Tripathi,
  • Anviksha Anviksha,
  • M. Sudhakara Reddy,
  • Suchitra Rajput

摘要

Polymeric devices, such as polydimethylsiloxane (PDMS)-based devices, have been extensively used in various biomedical applications, from implantable devices to biosensors. Nevertheless, it is prone to colonization by microorganisms due to its hydrophobic nature, leading to device-associated infections. This study presents a simple polydopamine (PDA) coating on PDMS via dip coating technique, and the effect of coating duration on surface chemistry, stability, and partial broad-spectrum antimicrobial performance. The coatings were characterized using Fourier Transform Infrared (FTIR) spectroscopy, Energy Dispersive X-Ray analysis (EDX), and Scanning Electron Microscope (SEM). The optimum coating time of 12 h showed the maximum antimicrobial efficiency of 63.63% and 68.03% antibacterial activity against Staphylococcus aureus and Escherichia coli, respectively. The 12 h deposited coatings exhibited 97.33% antifungal activity against Candida albicans. Beyond 12 h of coating, the performance deteriorates due to the surface morphology. This work shows that PDA coating duration plays a critical role in promoting antibacterial and antifungal activities for applications in biomedicine and biomedical implants.