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<p>Cervical cancer remains a major cause of cancer related deaths among women globally, emphasizing the need for effective detection methods. In this study, we present a novel approach using a Fluorine doped tin oxide (F-SnO<sub>2</sub>) coated tapered fiber optic probe utilizing Lossy Mode Resonance (LMR) technique, further enhanced with an Indium-doped tin oxide (In-SnO<sub>2</sub>) bilayer. Tapering factor and film thickness were optimized based on penetration depth and power studies, with ideal parameters found at a tapering factor of 1.75, monolayer thickness of 350–450&#xa0;nm, and bilayer thickness of 200&#xa0;nm each. Surface modification with In-SnO<sub>2</sub> significantly boosts the sensor’s sensitivity and specificity for cervical cancer biomarkers, outperforming F-SnO<sub>2</sub> based sensors by 6.4 times. Bilayer integration also reduces power loss by 1.88 times. Additionally, increasing film thickness from 300&#xa0;nm to 700&#xa0;nm results in a notable decrease in sensitivity and altered LMR emergence. These results demonstrate that the F-SnO<sub>2</sub> or In-SnO<sub>2</sub>-coated tapered fiber probe is a highly sensitive, cost-effective, and promising tool for early-stage cervical cancer detection, paving the way for timely diagnosis and improved patient care.</p>

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A Computational Approach to Optimize a Tapered Fiber Optic Probe with Doped Tin Oxide Bilayer Coating for Cervical Cancer Detection

  • 期刊论文

  • 发表日期：

    2026年6月22日

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  • Kavita Sharma,
  • Ghada A. Khouqeer,
  • Basma A. El-Badry,
  • Preeta Sharan,
  • Maha R. Elsyed

摘要

Cervical cancer remains a major cause of cancer related deaths among women globally, emphasizing the need for effective detection methods. In this study, we present a novel approach using a Fluorine doped tin oxide (F-SnO2) coated tapered fiber optic probe utilizing Lossy Mode Resonance (LMR) technique, further enhanced with an Indium-doped tin oxide (In-SnO2) bilayer. Tapering factor and film thickness were optimized based on penetration depth and power studies, with ideal parameters found at a tapering factor of 1.75, monolayer thickness of 350–450 nm, and bilayer thickness of 200 nm each. Surface modification with In-SnO2 significantly boosts the sensor’s sensitivity and specificity for cervical cancer biomarkers, outperforming F-SnO2 based sensors by 6.4 times. Bilayer integration also reduces power loss by 1.88 times. Additionally, increasing film thickness from 300 nm to 700 nm results in a notable decrease in sensitivity and altered LMR emergence. These results demonstrate that the F-SnO2 or In-SnO2-coated tapered fiber probe is a highly sensitive, cost-effective, and promising tool for early-stage cervical cancer detection, paving the way for timely diagnosis and improved patient care.