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<p>Recently, the bioactive polysaccharides have not been extensively explored for development of bioactive wound dressing. Hence, moringa gum has been utilized to develop the hydrogel by graft copolymerization of poly(2-hydroxyethylmethacrylate phosphate) in the presence a multifunctional crosslinker for use in drug delivery (DD) application. The hydrogel were characterized by FESEM, EDS, AFM, XRD FTIR, solid state <sup>13</sup>C-NMRand TGA and DSC. The DD, wound sorption, biocompatibility, antioxidant, mucoadhesion, and antibacterial properties along with mechanical and oxygen/water permeability aspects. The sustained delivery of minocycline from hydrogel governed by a non-Fickian diffusion mechanism &amp; release data was best described by first-order kinetic model. The one gram dressings retained 5.59 ± 0.24&#xa0;g of wound fluid, which is beneficial in preserving a moist surrounding for efficient wound healing. The dressing materials exhibited antioxidant activity quantified as 74.67 ± 1.35&#xa0;µg gallic acid equivalentsby the F-C assay. The material illustrated notable mucoadhesion and required detachment force of 153.00 ± 13.00 mN from the mucosal surface for its separation. The hydrogels elucidated biocompatibility observed from minimal hemolytic effect, indicating safe interaction with the biological system. Hydrogel dressing expressed antibacterial properties that significantly enhanced after drug encapsulation. Further, the web-like network structure was permeable to the diffusion of water vapor and oxygen. The findings of various physicochemical and biomedical properties suggested their suitability for use as wound dressing materials.</p>

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Designing of pH Sensing Dressing Materials by Network Formation Through Chemical-Physical Interactions for Drug Delivery Applications

  • 期刊论文

  • 发表日期：

    2026年5月12日

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  • Rajesh Kumar,
  • Shefali Sharma,
  • Baljit Singh

摘要

Recently, the bioactive polysaccharides have not been extensively explored for development of bioactive wound dressing. Hence, moringa gum has been utilized to develop the hydrogel by graft copolymerization of poly(2-hydroxyethylmethacrylate phosphate) in the presence a multifunctional crosslinker for use in drug delivery (DD) application. The hydrogel were characterized by FESEM, EDS, AFM, XRD FTIR, solid state 13C-NMRand TGA and DSC. The DD, wound sorption, biocompatibility, antioxidant, mucoadhesion, and antibacterial properties along with mechanical and oxygen/water permeability aspects. The sustained delivery of minocycline from hydrogel governed by a non-Fickian diffusion mechanism & release data was best described by first-order kinetic model. The one gram dressings retained 5.59 ± 0.24 g of wound fluid, which is beneficial in preserving a moist surrounding for efficient wound healing. The dressing materials exhibited antioxidant activity quantified as 74.67 ± 1.35 µg gallic acid equivalentsby the F-C assay. The material illustrated notable mucoadhesion and required detachment force of 153.00 ± 13.00 mN from the mucosal surface for its separation. The hydrogels elucidated biocompatibility observed from minimal hemolytic effect, indicating safe interaction with the biological system. Hydrogel dressing expressed antibacterial properties that significantly enhanced after drug encapsulation. Further, the web-like network structure was permeable to the diffusion of water vapor and oxygen. The findings of various physicochemical and biomedical properties suggested their suitability for use as wound dressing materials.