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<p><i>Polycarpaea corymbosa</i> is known for its diverse bioactive properties and significant biomedical potential. In this study, an eco-friendly green synthesis approach was used to produce zinc oxide nanoparticles (ZnONPs) from the leaf extract of <i>P. corymbosa</i>. The synthesized ZnONPs were characterized using UV-Vis spectroscopy, FTIR, XRD, SEM with EDAX and zeta potential analysis. UV-Vis spectroscopy confirmed nanoparticle formation with an absorption peak at 319&#xa0;nm. FTIR revealed key functional groups such as alkenes and carboxylic acids, while XRD confirmed the crystalline structure. SEM images showed predominantly spherical nanoparticles, and EDAX confirmed the presence of zinc and oxygen. The zeta potential value of − 12.3 mV indicated good nanoparticle stability. The ZnONPs exhibited strong antibacterial activity, producing a 10&#xa0;mm inhibition zone against <i>Bacillus subtilis</i>. Antioxidant assays (DPPH and ABTS) demonstrated notable free-radical scavenging activity. The nanoparticles also showed significant antidiabetic potential by inhibiting both α-amylase and α-glucosidase enzymes. In anticancer studies, the ZnONPs reduced the viability of A431 skin cancer cells by 54.74%, with EGFR showing the highest binding affinity (− 5.63&#xa0;kcal/mol) in molecular docking. Additionally, the nanoparticles displayed excellent photocatalytic performance, achieving 70% dye degradation. Overall, ZnONPs synthesized from <i>P. corymbosa</i> show strong potential for biomedical applications including antibacterial, antioxidant, antidiabetic and anticancer activities as well as environmental applications such as dye degradation, offering promising avenues for therapeutic development and environmental remediation.</p> Graphical abstract <p></p>

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Multifunctional Zinc Oxide Nanoparticles Synthesized from Polycarpaea Corymbosa: A Green Approach To Biomedical and Environmental Solutions

  • 期刊论文

  • 发表日期：

    2026年3月10日

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  • Dharmalingam Kirubakaran,
  • Joseline Sofia Sharon,
  • K. J. Senthil Kumar

摘要

Polycarpaea corymbosa is known for its diverse bioactive properties and significant biomedical potential. In this study, an eco-friendly green synthesis approach was used to produce zinc oxide nanoparticles (ZnONPs) from the leaf extract of P. corymbosa. The synthesized ZnONPs were characterized using UV-Vis spectroscopy, FTIR, XRD, SEM with EDAX and zeta potential analysis. UV-Vis spectroscopy confirmed nanoparticle formation with an absorption peak at 319 nm. FTIR revealed key functional groups such as alkenes and carboxylic acids, while XRD confirmed the crystalline structure. SEM images showed predominantly spherical nanoparticles, and EDAX confirmed the presence of zinc and oxygen. The zeta potential value of − 12.3 mV indicated good nanoparticle stability. The ZnONPs exhibited strong antibacterial activity, producing a 10 mm inhibition zone against Bacillus subtilis. Antioxidant assays (DPPH and ABTS) demonstrated notable free-radical scavenging activity. The nanoparticles also showed significant antidiabetic potential by inhibiting both α-amylase and α-glucosidase enzymes. In anticancer studies, the ZnONPs reduced the viability of A431 skin cancer cells by 54.74%, with EGFR showing the highest binding affinity (− 5.63 kcal/mol) in molecular docking. Additionally, the nanoparticles displayed excellent photocatalytic performance, achieving 70% dye degradation. Overall, ZnONPs synthesized from P. corymbosa show strong potential for biomedical applications including antibacterial, antioxidant, antidiabetic and anticancer activities as well as environmental applications such as dye degradation, offering promising avenues for therapeutic development and environmental remediation.

Graphical abstract