Scholarlink

<p>Cell-dense bioprinting is emerging as a new class of <i>living manufacturing platforms</i>, in which cellular collectives simultaneously provide structure, biological activity, and functional output. In their recent <i>Cell</i> study, Wang et al. introduce CLINK (cell-dense bioINK), a biomaterial-minimalistic, photoactivated strategy that directly uses living cells as printable, photoresponsive building blocks. Beyond summarizing this advance, this Commentary critically positions CLINK relative to existing scaffold-free and aggregate-based bioprinting approaches, highlights the quantitative benchmarks supporting its claim of native cellular resolution, and discusses key translational challenges—including scalability, reproducibility, and regulatory considerations—that will determine whether cell-dense bioprinting can mature into clinically deployable living devices.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Cell-Dense Bioprinting as a Living Device for Engineering Tissues at Native Cellular Resolution

  • 期刊论文

  • 发表日期：

    2026年3月10日

查看全文
  • Jinwei Zhang

摘要

Cell-dense bioprinting is emerging as a new class of living manufacturing platforms, in which cellular collectives simultaneously provide structure, biological activity, and functional output. In their recent Cell study, Wang et al. introduce CLINK (cell-dense bioINK), a biomaterial-minimalistic, photoactivated strategy that directly uses living cells as printable, photoresponsive building blocks. Beyond summarizing this advance, this Commentary critically positions CLINK relative to existing scaffold-free and aggregate-based bioprinting approaches, highlights the quantitative benchmarks supporting its claim of native cellular resolution, and discusses key translational challenges—including scalability, reproducibility, and regulatory considerations—that will determine whether cell-dense bioprinting can mature into clinically deployable living devices.