<p><?tk 4?>Smart contact lenses (SCLs) have emerged as transformative platforms for non-invasive, continuous health monitoring by integrating flexible electronics, biosensors, and communication modules within soft ocular substrates. This review provides a comprehensive analysis of the evolution of SCL technologies from early prototypes in the early 2000s to recent advances enabling multi-analyte detection, real-time diagnostics, and wireless data transfer. We examine material innovations including hydrogels, elastomers, and advanced nanomaterials such as graphene, gold nanoparticles, and MXenes, which have enhanced the lenses biocompatibility, optical clarity, and sensing performance. The paper further explores power supply mechanisms such as near-field communication (NFC), triboelectric nanogenerators, and photovoltaics, along with wireless modules for on-lens and off-lens data processing. Biomedical applications spanning glucose monitoring, intraocular pressure sensing, cortisol and lactate detection, and emerging roles in cancer biomarker sensing are critically reviewed. Additionally, we discuss the growing integration of artificial intelligence for sensor calibration, personalized analytics, and cloud connectivity. The commercial and regulatory landscape is analyzed, including current market prototypes, patent trends, and FDA/CE approval frameworks. Finally, future directions are proposed, emphasizing multi-biomarker detection, energy-efficient architectures, and integration with telemedicine and IoT ecosystems. This review highlights the potential of SCLs to redefine point-of-care diagnostics and outlines the scientific, technological, and regulatory milestones necessary to translate laboratory breakthroughs into widespread clinical use.</p>