<p>Fast-dissolving drug delivery systems (FDDDS) and rapid melts are transforming the scope of oral drug delivery. These are a more convenient and patient-friendly option, especially for paediatrics, geriatrics, and patients who are dysphagic, as they quickly dissolve in the mouth with no water requirement. Given the extent of FDDDS, this review embraces their formulation aspects, highlights and limitations, and drug absorption influencing factors in the body. It examines various formulation processes such as lyophilization, direct compression, moulding, sublimation, spray drying, and film-based methods alongside novel technologies like 3D printing and electrospinning. Different excipients in FDDDS such as polymers, sweeteners, flavouring agents, and super disintegrants which render these systems effective and pleasant to use have been elaborated. Different research findings have established the capability of FDDDS to improve drug solubility, bioavailability and patient compliance. In spite of the need for efficient taste masking and poor drug loading, ongoing advancements are facilitating the development of personalized and convenient oral drug delivery systems. This review is intended to serve as an useful guide for researchers and formulators interested in the design of next-generation drug delivery systems.</p> Graphical Abstract <p></p>