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<p>Psoriasis is a chronic, immune-mediated inflammatory skin disorder marked by excessive keratinocyte proliferation, the formation of red, scaly plaques, and persistent skin inflammation. It is often accompanied by systemic complications such as metabolic syndrome, cardiovascular disorders, and psoriatic arthritis. Despite the wide range of available treatments including topical corticosteroids, vitamin D analogs, systemic immunosuppressants, and biologic agents the effective management of psoriasis remains a major challenge. Conventional therapies often fall short due to issues such as inadequate skin penetration, undesirable systemic side effects, poor patient compliance, and the inability to achieve sustained or localized drug delivery. These limitations highlight the need for advanced drug delivery systems that can improve therapeutic outcomes while minimizing adverse effects. Nanosuspensions, which are submicron dispersions composed of pure drug particles stabilized by surfactants, have recently gained attention as a promising strategy to enhance the solubility, stability, and bioavailability of poorly water-soluble drugs. Their distinct physicochemical properties such as a high surface area, faster dissolution rate, and adaptability for targeted delivery make them particularly suitable for topical applications in psoriasis management. By facilitating deeper skin penetration, prolonging drug residence time at the site of action, and enabling controlled release, nanosuspensions can effectively overcome the drawbacks of conventional formulations. Furthermore, they offer formulation flexibility, allowing the incorporation of multiple therapeutic agents, especially lipophilic drugs that typically show limited efficacy in traditional dosage forms. This review focuses on exploring the potential of nanosuspension-based drug delivery systems in psoriasis therapy, emphasizing their formulation methods, mechanisms of action, and therapeutic implications. In essence, nanosuspensions represent a next-generation, patient-friendly approach with the potential to revolutionize topical psoriasis treatment by enhancing drug bioavailability, improving efficacy, and ensuring better long-term disease management.</p>

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Advancing Psoriasis Care: Efficacy of Nanosuspensions in Targeted Skin Therapies

  • 期刊论文

  • 发表日期：

    2025年12月14日

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  • Akshay Parihar,
  • Himanshu Paliwal,
  • Jasveer Kaur,
  • Swati Pal,
  • Bhupendra Prajapati,
  • Ravinder Sharma

摘要

Psoriasis is a chronic, immune-mediated inflammatory skin disorder marked by excessive keratinocyte proliferation, the formation of red, scaly plaques, and persistent skin inflammation. It is often accompanied by systemic complications such as metabolic syndrome, cardiovascular disorders, and psoriatic arthritis. Despite the wide range of available treatments including topical corticosteroids, vitamin D analogs, systemic immunosuppressants, and biologic agents the effective management of psoriasis remains a major challenge. Conventional therapies often fall short due to issues such as inadequate skin penetration, undesirable systemic side effects, poor patient compliance, and the inability to achieve sustained or localized drug delivery. These limitations highlight the need for advanced drug delivery systems that can improve therapeutic outcomes while minimizing adverse effects. Nanosuspensions, which are submicron dispersions composed of pure drug particles stabilized by surfactants, have recently gained attention as a promising strategy to enhance the solubility, stability, and bioavailability of poorly water-soluble drugs. Their distinct physicochemical properties such as a high surface area, faster dissolution rate, and adaptability for targeted delivery make them particularly suitable for topical applications in psoriasis management. By facilitating deeper skin penetration, prolonging drug residence time at the site of action, and enabling controlled release, nanosuspensions can effectively overcome the drawbacks of conventional formulations. Furthermore, they offer formulation flexibility, allowing the incorporation of multiple therapeutic agents, especially lipophilic drugs that typically show limited efficacy in traditional dosage forms. This review focuses on exploring the potential of nanosuspension-based drug delivery systems in psoriasis therapy, emphasizing their formulation methods, mechanisms of action, and therapeutic implications. In essence, nanosuspensions represent a next-generation, patient-friendly approach with the potential to revolutionize topical psoriasis treatment by enhancing drug bioavailability, improving efficacy, and ensuring better long-term disease management.