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<p>Tannic acid and sodium alginate are both naturally occurring polymeric substances that can be combined. In this study, we aim to synthesize we suggest new environmentally friendly nanoformulations for use in biomedical applications. The formation of sodium alginate-tannic acid nanoformulation was primarily confirmed by colour changes and visual observation. They were physicochemically characterised through UV–Visible spectroscopy, Fourier transformation infrared spectroscopy, XRD- crystal pattern, and morphologically analysed through SEM, exhibiting uniform monodisperse and highly stable sodium alginate-Tannic acid nanoformulation particles in size 51.11&#xa0;nm. The UV–Vis spectroscopy has confirmed the formation of the nanoformulation two peaks observed at 355 and 390&#xa0;nm. The bioactive functional group and crystalline nature of nanoformulations were determined. With the use of natural polymers in biomedical applications growing, alginate-based systems have generated plenty of research and have been evaluated for alpha-amylase, 48–84% of inhibition at the highest concentration (10–50&#xa0;µg/mL: IC<sub>50</sub> value of 10.11&#xa0;µg/mL), similarly, beta-glucosidase, 51–82% of inhibition at the highest concentration, 10–50&#xa0;µg/mL (IC<sub>50:</sub> 8.92&#xa0;µg/mL), synthesized nanoformulation exhibit strong antioxidant activity showed statistically significance using Two-Way ANOVA (<i>P</i> value &lt; 0.0001, 0.0183, 0.0353: IC<sub>50</sub> value of 14.7959: <i>R</i><sup>2</sup> = 0.9856). Furthermore, overall results show benefiting from the strong antidiabetic activity and antioxidant activity compared with standard ascorbic acid. These findings provide insight into the therapeutic potential of biologically synthesized sodium alginate-tannic acid nanoformulation, paving the way for future nanomedicine research and development in diabetes management.</p>

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Comparative In Vitro Evaluation of Antidiabetic and Antioxidant Activities of Alginate, Tannic Acid, and Their Nanoformulation

  • 期刊论文

  • 发表日期：

    2025年10月15日

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  • Balasaranya Ayyappan,
  • Banuppriya Palani,
  • Santhoshkumar Jayakodi,
  • Rajeshkumar Shanmugam

摘要

Tannic acid and sodium alginate are both naturally occurring polymeric substances that can be combined. In this study, we aim to synthesize we suggest new environmentally friendly nanoformulations for use in biomedical applications. The formation of sodium alginate-tannic acid nanoformulation was primarily confirmed by colour changes and visual observation. They were physicochemically characterised through UV–Visible spectroscopy, Fourier transformation infrared spectroscopy, XRD- crystal pattern, and morphologically analysed through SEM, exhibiting uniform monodisperse and highly stable sodium alginate-Tannic acid nanoformulation particles in size 51.11 nm. The UV–Vis spectroscopy has confirmed the formation of the nanoformulation two peaks observed at 355 and 390 nm. The bioactive functional group and crystalline nature of nanoformulations were determined. With the use of natural polymers in biomedical applications growing, alginate-based systems have generated plenty of research and have been evaluated for alpha-amylase, 48–84% of inhibition at the highest concentration (10–50 µg/mL: IC50 value of 10.11 µg/mL), similarly, beta-glucosidase, 51–82% of inhibition at the highest concentration, 10–50 µg/mL (IC50: 8.92 µg/mL), synthesized nanoformulation exhibit strong antioxidant activity showed statistically significance using Two-Way ANOVA (P value < 0.0001, 0.0183, 0.0353: IC50 value of 14.7959: R2 = 0.9856). Furthermore, overall results show benefiting from the strong antidiabetic activity and antioxidant activity compared with standard ascorbic acid. These findings provide insight into the therapeutic potential of biologically synthesized sodium alginate-tannic acid nanoformulation, paving the way for future nanomedicine research and development in diabetes management.