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<p>Diabetes is a metabolic disorder that increases blood glucose levels and delays wound healing. Several bioactive molecules found in plants have antimicrobial and pharmaceutical properties, which make them effective in controlling metabolic diseases. In this study we synthesized ZnO-NPs using aqueous leaf extract of <i>Breynia vitis-idaea</i>. The synthesized ZnO-NPs were characterized using UV–Vis spectrophotometer, XRD, FT-IR, SEM&#xa0;with&#xa0;EDX, zeta potential and HRTEM. The antibacterial potential of ZnO-NPs was checked using pathogenic bacteria. Antioxidant property was calculated by DPPH and phosphomolybdenum assays. α- amylase and α-glucosidase assays were done to check the anti-diabetic property. UV–Vis absorption peak of green synthesized ZnO-NPs showed the absorbance peak of 340&#xa0;nm, the hexagonal wurtzite of crystal structure confirmed by XRD analysis. FT-IR spectrum revealed the functional groups namely alcohol, phenol, alkyl group, zinc carboxylate, alkenes, aromatic ring, and amino acid. SEM with EDX showed nanoparticles to be spherical in shape, with an average size of 69&#xa0;nm. Zeta potential analysis shows − 21.8&#xa0;mV surface charge. HRTEM analysis revealed the spherical shaped structure with the size range of 20–100&#xa0;nm. ZnO-NPs inhibit the activities of α-amylase and α-glucosidase enzymes. The finding exhibits that the green synthesized ZnO-NPs have potent antibacterial and antidiabetic properties, therefore it can further explored for their biomedical applications.</p> Graphical Abstract <p></p>

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Spectral Analysis and In Vitro Antibacterial and Antidiabetic Potential of Zinc Oxide Nanoparticles Synthesized from Aqueous Leaf Extract of Breynia vitis-idaea

  • 期刊论文

  • 发表日期：

    2025年7月23日

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  • Mathiazhakan Lavanya,
  • Muthugounder Subaramanian Shivakumar,
  • Kuppusamy Selvam

摘要

Diabetes is a metabolic disorder that increases blood glucose levels and delays wound healing. Several bioactive molecules found in plants have antimicrobial and pharmaceutical properties, which make them effective in controlling metabolic diseases. In this study we synthesized ZnO-NPs using aqueous leaf extract of Breynia vitis-idaea. The synthesized ZnO-NPs were characterized using UV–Vis spectrophotometer, XRD, FT-IR, SEM with EDX, zeta potential and HRTEM. The antibacterial potential of ZnO-NPs was checked using pathogenic bacteria. Antioxidant property was calculated by DPPH and phosphomolybdenum assays. α- amylase and α-glucosidase assays were done to check the anti-diabetic property. UV–Vis absorption peak of green synthesized ZnO-NPs showed the absorbance peak of 340 nm, the hexagonal wurtzite of crystal structure confirmed by XRD analysis. FT-IR spectrum revealed the functional groups namely alcohol, phenol, alkyl group, zinc carboxylate, alkenes, aromatic ring, and amino acid. SEM with EDX showed nanoparticles to be spherical in shape, with an average size of 69 nm. Zeta potential analysis shows − 21.8 mV surface charge. HRTEM analysis revealed the spherical shaped structure with the size range of 20–100 nm. ZnO-NPs inhibit the activities of α-amylase and α-glucosidase enzymes. The finding exhibits that the green synthesized ZnO-NPs have potent antibacterial and antidiabetic properties, therefore it can further explored for their biomedical applications.

Graphical Abstract