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<p><i>Lantana camara</i> leaves extracted essential oil has been utilized in the treatment of inflammation, swelling, and other dermatological ailments. However, direct application of <i>Lantana</i> essential oil may cause itchy skin, allergic reaction and lower its effectiveness owing to poor aqueous solubility. Therefore, the present study deals with the characterisation of <i>Lantana camara</i> leaves extracted essential oil (LEO) and fabrication (fluid fiber mechanism), optimization of the essential oil loaded with oleogels. Pseudo ternary phase diagram was developed for selecting the concentration ranges (%v/v) of olive oil (apolar solvent), Span 80 (organogelator), Tween 80 (co-organogelator) and water to develop an experimental design. Box behnken design was adapted to optimize the formulations via polynomial quadratic equations on each dependent variable (percentage spreadability, viscosity at 1&#xa0;rpm (25&#xa0;°C), and cumulative percentage LEO release at 8&#xa0;h) and characterized on the basis of applicability parameters, thermal, stability profile, and in vitro anti-microbial potency against <i>Propionibacterium acnes</i>. GC–MS study demonstrated the presence of major phyto-constituents (linalool, β-caryophyllene, and β-elemene) in LEO. The optimized LEO loaded oleogel, comprising of olive oil (40%v/v), Span 80-Tween 80 (30%v/v in the ratio of 2:1), and water (30%v/v) demonstrated satisfactory percentage spreadability (85.98% ± 0.28), viscosity (156,000 cps ± 3.2) at 1&#xa0;rpm (25&#xa0;°C), and 82.20% ± 0.08 of LEO release (at 8&#xa0;h) following zero order kinetics with good stability profile. The concentration dependent in vitro anti-microbial activity of the optimized formulation (MIC = 6.25&#xa0;mg/ml) with minimal percentage bias between actual and observed values (0.64–1.52%) confirming the potentiality of <i>Lantana</i> essential oil loaded oleogel for treatment of acne.</p> Graphical Abstract <p></p>

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Therapeutic Oleogels Incorporating Lantana Essential Oil: Formulation Strategies and Characterization Studies

  • 期刊论文

  • 发表日期：

    2025年7月24日

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  • Dipanjana Ash,
  • Sankhadip Bose,
  • Biswajit Basu,
  • Sailee Chowdhury,
  • Bhupendra Prajapati

摘要

Lantana camara leaves extracted essential oil has been utilized in the treatment of inflammation, swelling, and other dermatological ailments. However, direct application of Lantana essential oil may cause itchy skin, allergic reaction and lower its effectiveness owing to poor aqueous solubility. Therefore, the present study deals with the characterisation of Lantana camara leaves extracted essential oil (LEO) and fabrication (fluid fiber mechanism), optimization of the essential oil loaded with oleogels. Pseudo ternary phase diagram was developed for selecting the concentration ranges (%v/v) of olive oil (apolar solvent), Span 80 (organogelator), Tween 80 (co-organogelator) and water to develop an experimental design. Box behnken design was adapted to optimize the formulations via polynomial quadratic equations on each dependent variable (percentage spreadability, viscosity at 1 rpm (25 °C), and cumulative percentage LEO release at 8 h) and characterized on the basis of applicability parameters, thermal, stability profile, and in vitro anti-microbial potency against Propionibacterium acnes. GC–MS study demonstrated the presence of major phyto-constituents (linalool, β-caryophyllene, and β-elemene) in LEO. The optimized LEO loaded oleogel, comprising of olive oil (40%v/v), Span 80-Tween 80 (30%v/v in the ratio of 2:1), and water (30%v/v) demonstrated satisfactory percentage spreadability (85.98% ± 0.28), viscosity (156,000 cps ± 3.2) at 1 rpm (25 °C), and 82.20% ± 0.08 of LEO release (at 8 h) following zero order kinetics with good stability profile. The concentration dependent in vitro anti-microbial activity of the optimized formulation (MIC = 6.25 mg/ml) with minimal percentage bias between actual and observed values (0.64–1.52%) confirming the potentiality of Lantana essential oil loaded oleogel for treatment of acne.

Graphical Abstract