<p>The growing regulatory pressures and environmental concerns in the various industries including pharmaceuticals, food, cosmetics, and bioenergy have amplified the quest to develop sustainable and eco-efficient extraction methods. The traditional solvent-based extractions have been linked to great amounts of energy use, toxic chemicals, and dangerous waste productions, which makes it necessary to come up with alternatives that are greener. In this review, an in-depth account of emerging eco-efficient extraction technologies is given and solvent-free extractions, new green solvents, and assisted extractions have been highlighted. Solventless methods such as cold pressing, steam distillation, and supercritical fluid extraction offer significant environmental benefits while preserving the integrity and quality of the final product. At the same time, there is the use of alternative solvents, such as ionic liquids, deep eutectic solvents, and bio-based solvents, which provide safer, biodegradable, and effective extraction media. Assisted extractions such as ultrasound-assisted, microwave-assisted, enzymatic, and supercritical fluid-assisted extractions improve the efficiency of the process, extractions yields, and scalability, presenting a compromise between environmental sustainability and industrial feasibility. Also discussed in the review are the working principles, technology development trends, as well as practical uses of these techniques, which indicate their transformative power, both in the laboratory and industry. Issues like optimization of the process, scale-up, integration with existing hybrid technologies, and acceptance by regulatory bodies are critically discussed. The results highlight the idea that implementing these green extraction technologies is in line with global sustainability ambitions but also leads to better economic and production performance. Researchers, industry practitioners, and policymakers looking to establish green extraction solutions in biomedical and related practices can find the work resourceful.</p> Graphical Abstract <p></p>