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<p>These biomedical applications find supramolecular polymers (SPs) to be highly innovative because of their dynamic and reversible and stimuli-responsive characteristics. The formation of these polymers happens through intermolecular forces that include hydrogen bonding and π–π stacking and host–guest chemistry and metal–ligand coordination and enables superior manipulation of material properties. This control facilitates the creation of intelligent, adaptive, and biomimetic systems. This review delves into the core principles, molecular design strategies, and biomedical attributes of SPs, with a particular emphasis on their role in drug delivery. This part explores basic design elements which include single or multiple functional building components and modular assembly elements for response mechanisms and biomimetic design patterns. The biomedical advantages of SPs depend heavily on their ability to reverse themselves along with their capacity for adaptation in addition to their compatibility with biological systems and their response to external stimuli which all work together to deliver targeted drug delivery. This review examines SP-based drug delivery methods such as micelles, nanoparticles, injectable hydrogels, and vesicles along with capsules because they encapsulate several therapeutic agents and control drug releases through spatial–temporal parameters. The latest developments in the field are demonstrated through examples of multi-responsive systems and supramolecular bioadhesives as well as hybrid materials. The review examines the clinical and translational problems connected to STs through detailed discussions about scalability, stability, and regulatory problems and presents possible solutions. SPs in biomedicine have the potential to grow through three areas of development: smart implants, biosensing, immune modulation alongside artificial intelligence for enhanced formulation capability and individualized medicine and improved real-time monitoring of SP activities. Supramolecular chemistry research development for biomedical applications will advance SPs into the leading drug delivery method to produce patient-specific therapeutic treatments of the future.</p>

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Supramolecular Polymers in Hybrid Drug Delivery Systems: A Promising Platform for Targeted and Responsive Therapeutics

  • 期刊论文

  • 发表日期：

    2025年7月10日

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  • Elizabeth Rani Edwin,
  • Yuvaraj Muthu,
  • Prabakaran Sankar,
  • Sakthi Sanjana Deenadhayalan,
  • Bharath Selvam,
  • Karthikeyan Elumalai

摘要

These biomedical applications find supramolecular polymers (SPs) to be highly innovative because of their dynamic and reversible and stimuli-responsive characteristics. The formation of these polymers happens through intermolecular forces that include hydrogen bonding and π–π stacking and host–guest chemistry and metal–ligand coordination and enables superior manipulation of material properties. This control facilitates the creation of intelligent, adaptive, and biomimetic systems. This review delves into the core principles, molecular design strategies, and biomedical attributes of SPs, with a particular emphasis on their role in drug delivery. This part explores basic design elements which include single or multiple functional building components and modular assembly elements for response mechanisms and biomimetic design patterns. The biomedical advantages of SPs depend heavily on their ability to reverse themselves along with their capacity for adaptation in addition to their compatibility with biological systems and their response to external stimuli which all work together to deliver targeted drug delivery. This review examines SP-based drug delivery methods such as micelles, nanoparticles, injectable hydrogels, and vesicles along with capsules because they encapsulate several therapeutic agents and control drug releases through spatial–temporal parameters. The latest developments in the field are demonstrated through examples of multi-responsive systems and supramolecular bioadhesives as well as hybrid materials. The review examines the clinical and translational problems connected to STs through detailed discussions about scalability, stability, and regulatory problems and presents possible solutions. SPs in biomedicine have the potential to grow through three areas of development: smart implants, biosensing, immune modulation alongside artificial intelligence for enhanced formulation capability and individualized medicine and improved real-time monitoring of SP activities. Supramolecular chemistry research development for biomedical applications will advance SPs into the leading drug delivery method to produce patient-specific therapeutic treatments of the future.