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<p>Metallic nanoparticle-decorated graphene oxide (MNP-GO) nanocomposites have emerged as a promising platform for advanced wound healing applications. The incorporation of metallic nanoparticles such as silver (Ag), gold (Au), zinc oxide (ZnO), and copper oxide (CuO) onto the graphene oxide (GO) surface enhances the nanocomposite's therapeutic efficacy, enabling infection prevention, immune modulation, and accelerated tissue repair. MNP-GO nanocomposites exhibit potent antibacterial activity against drug-resistant bacteria, modulate inflammatory responses, reduce oxidative stress, and promote fibroblast proliferation, collagen synthesis, and angiogenesis, creating an optimal environment for wound healing. Their integration into smart wound dressings and controlled drug delivery systems presents new opportunities for personalized and real-time wound management. However, clinical translation requires further research on long-term safety, biocompatibility, stability, and scalable production. Addressing these challenges through interdisciplinary collaborations and continued advancements in nanotechnology could revolutionize modern wound care strategies, providing faster healing, reduced complications, and improved patient outcomes. This review provides a comprehensive overview of the synthesis, characterization, and biomedical applications of MNP-GO nanocomposites in wound healing, highlighting their potential as next-generation therapeutic agents.</p> Graphical Abstract <p></p>

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Metallic Nanoparticle-Functionalized Graphene Oxide Nanocomposites for Wound Healing: A Comprehensive Review

  • 期刊论文

  • 发表日期：

    2025年7月11日

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  • Elizabeth Rani Edwin,
  • D. Sakthi Sanjana,
  • Bellarmin Michael,
  • Sivaprakash Kathiresan,
  • Karthikeyan Elumalai,
  • Nandhini Jayaprakash

摘要

Metallic nanoparticle-decorated graphene oxide (MNP-GO) nanocomposites have emerged as a promising platform for advanced wound healing applications. The incorporation of metallic nanoparticles such as silver (Ag), gold (Au), zinc oxide (ZnO), and copper oxide (CuO) onto the graphene oxide (GO) surface enhances the nanocomposite's therapeutic efficacy, enabling infection prevention, immune modulation, and accelerated tissue repair. MNP-GO nanocomposites exhibit potent antibacterial activity against drug-resistant bacteria, modulate inflammatory responses, reduce oxidative stress, and promote fibroblast proliferation, collagen synthesis, and angiogenesis, creating an optimal environment for wound healing. Their integration into smart wound dressings and controlled drug delivery systems presents new opportunities for personalized and real-time wound management. However, clinical translation requires further research on long-term safety, biocompatibility, stability, and scalable production. Addressing these challenges through interdisciplinary collaborations and continued advancements in nanotechnology could revolutionize modern wound care strategies, providing faster healing, reduced complications, and improved patient outcomes. This review provides a comprehensive overview of the synthesis, characterization, and biomedical applications of MNP-GO nanocomposites in wound healing, highlighting their potential as next-generation therapeutic agents.

Graphical Abstract