<p>Innovative methods for therapy and diagnosis have been made possible by nanomedicine, with electrosomes emerging as a ground-breaking development in targeted drug delivery. Electrosomes are customized nanocarriers that use their distinct electrostatic capabilities and biocompatible structure to deliver medicinal medicines precisely. These nanocarriers have shown a great deal of promise in improving the effectiveness of therapies for neurological illnesses, cancer therapy, and gene delivery. The creation of electrosomes is examined in this work, with particular attention paid to their production, mode of action, and benefits over other common nanocarriers, such as liposomes, exosomes, and dendrimers. The unique property of electrosomes is their capacity to encapsulate a wide range of therapeutic agents, such as tiny molecules, proteins, peptides, and nucleic acids, and to release these agents in response to external stimuli like light, heat, or electrical impulses. They constitute an important development in the field of nanocarrier technology due to their capacity to enhance drug stability, bioavailability, and non-invasive delivery. Through regulated release processes, electrosomes also maximize drug absorption while minimizing off-target effects. Nevertheless, there are still difficulties, such as intricate production procedures, scalability problems, and regulatory worries. The goal of current research is to get past these obstacles in order to improve the effectiveness and safety of electrosomes in medicinal applications. In future of nanomedicine, electrosomes are opening the door to more efficient, patient-specific treatments by revolutionizing molecular and precision therapeutics.</p> Graphical Abstract <p></p>