<p>The combination of optomechanical engineering and magneto-responsive polymers (MRPs) has transformed the creation of next-generation prostheses, particularly for those suffering from neuromuscular deficits caused by new infectious illnesses. This study looks at the possibilities of MRP-based artificial muscles for survivors of melioidosis (caused by <i>Burkholderia pseudomallei</i>) and chytridiomycosis (induced by <i>Batrachochytrium</i> spp.), both of which cause significant locomotor impairment and tissue degradation. The recent advances in optomechanical actuation, in which light and magnetic fields affect polymeric structures, show great potential for imitating human muscle action. The researchers want to improve prosthesis flexibility, energy efficiency, and biomechanical precision by exploiting the dynamic interaction of light-induced thermal effects, magnetomechanical deformation, and biocompatible nanocomposites. This study looks at material breakthroughs such as hybrid elastomers, shape-memory polymers, and bioinspired hydrogels that provide real-time, customizable mechanical responses customized to patient mobility demands. Furthermore, we evaluate current patents and developing technologies that enhance sensor-integrated MRPs, allowing for smooth contact with the nervous system and adaptive feedback control in prosthetic limbs. We emphasize present constraints, such as stability, long-term biocompatibility, and scalability, and propose future research areas to improve opto-magnetomechanical synergy in prosthetic devices. This review emphasizes the transformative potential of optomechanically engineered MRPs in restoring functional mobility for melioidosis and chytridiomycosis survivors, laying the groundwork for broader applications in neuromuscular rehabilitation by bridging interdisciplinary approaches in materials science, bioengineering, and regenerative medicine.</p> Graphical Abstract <p>Illustration explaining Magneto-Responsive Polymers: Fundamentals and Biomedical Applications, Mechanisms of Magnetic Actuation in Polymer Networks, Optomechanical Engineering in Prosthetics and Prosthetic Design Using Optomechanical and Magneto-Responsive Polymers</p> <p></p>