<p>Nanosuspension technology has emerged as a promising strategy for enhancing the solubility and bioavailability of poorly water-soluble drugs. This review critically evaluates the advancements in nanosuspension formulation and characterization techniques, focusing on their application in drug delivery. Nanosuspensions, submicron colloidal dispersions of pure drug particles stabilized by surfactants or polymers, offer distinct advantages over conventional formulations by improving dissolution rates, enhancing permeability, and enabling targeted delivery. However, despite these benefits, challenges such as broad particle size distributions and stability issues, including Ostwald ripening and aggregation, remain significant limitations. Formulation techniques such as high-pressure homogenization, wet milling, and precipitation offer scalability and reproducibility for industrial production, but each comes with its own set of drawbacks. For instance, high-pressure homogenization requires high energy input and may not be suitable for heat-sensitive compounds. Wet milling, though efficient, can result in broader particle size distributions and often necessitates the use of surfactants that can influence the drug’s bioactivity. Advanced characterization tools, including dynamic light scattering, scanning electron microscopy, and differential scanning calorimetry, enable precise control over particle size, stability, and drug release profiles. Despite this, achieving consistent batch-to-batch quality at large scale remains a challenge.</p>