<p>Smart nanomaterials have emerged as a promising solution to address the limitations of traditional materials for use in biomedical applications, particularly in the delivery of drugs and engineering in tissue. These materials can respond to specific stimuli, allowing for more precise and controlled therapeutic approaches. This review provides a comprehensive overview of the recent advancements in smart nanomaterials, focusing on their types, applications, challenges, and future directions. The article delves into many kinds of smart nanomaterials, shedding light on their distinct characteristics and possible uses. These include stimuli-responsive polymers, shape-memory materials, self-healing nanomaterials, and bioresponsive materials. The review then explores the applications of smart nanomaterials in drug delivery, such as controlled release systems, targeted delivery strategies, and smart nanoparticles. In tissue engineering, the article examines the use of smart scaffolds, dynamic nanomaterials, and bioresponsive materials for tissue regeneration. Despite smart nanomaterials’ enormous potential, a number of issues and restrictions are addressed, including biocompatibility, long-term stability, scalability, and regulatory hurdles. The review concludes by discussing the future directions of smart nanomaterials research, emphasizing the development of multi-functional materials, personalized medicine, biofabrication, and the integration of wearable technology.</p> Graphical Abstract <p></p>