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<p>This study aimed to investigate the properties, synergistic effects, and drug release kinetics of electrospun membranes (S1–S3). Specifically, S1 is a membrane composed of a polycaprolactone (PCL) and polyvinylpyrrolidone (PVP) blend in an 80:20 ratio, loaded with amoxicillin (AMX); S2 is a variant of S1 combined with S49B4 bioactive glass (BG); and S3 is a variant of S1 combined with surface-functionalized S49B4 bioactive glass (SFBG). Optimizing the electrospinning procedure allowed for producing membranes with diameters ranging from 110 to 550&#xa0;nm. Using a range of characterization techniques, the structure and morphology of the membrane, wettability, biodegradability, bioactivity, phase change, thermal properties, functional groups, mechanical properties, and drug release kinetics were all investigated. The inclusion of BG, SFBG, PVP, and AMX altered the properties of PCL. The hydrophilicity of the composite membrane also significantly increased. S1 displayed surface degradation in the bioactivity investigation of the samples in SBF, but adding BG (S2) and SFBG (S3) enhanced fiber integrity and encouraged hydroxyapatite formation. Notably, S1 showed significant ductility, while the addition of BG and SFBG in S2 and S3 increased the mechanical strength, although with a compromise in elasticity. S3 showed the highest drug-loading capacity, measuring 95.8 ± 0.8%, compared to S1 and S2. Zero-order, Higuchi, Kosmeyer-Peppas (K-P), and Peppas-Sahlin (P-S) kinetic models were used to fit the drug release data for all fibers; K-P fit S1 the best, while P-S fit S2 and S3. The results demonstrated that class II relaxations and Fickian diffusion controlled the drug transport mechanism. The release curves showed a faster phase that lasted up to 63&#xa0;days, followed by a slower burst release with an average release value of 46% within the first 24&#xa0;h. Thus, our work provides important insights into the properties and drug release capabilities of the composite S1–S3 membranes, suggesting their potential use in biomedical and tissue engineering applications<i>.</i></p>

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Evaluating the Bioactive Capability and Analysis of Amoxicillin Release Mechanisms in PCL/PVP Nanofibers using Bioactive Glass as a Drug Carrier

  • 期刊论文

  • 发表日期：

    2025年3月19日

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  • Oluwatosin David Abodunrin,
  • Meriame Bricha,
  • Khalil El Mabrouk

摘要

This study aimed to investigate the properties, synergistic effects, and drug release kinetics of electrospun membranes (S1–S3). Specifically, S1 is a membrane composed of a polycaprolactone (PCL) and polyvinylpyrrolidone (PVP) blend in an 80:20 ratio, loaded with amoxicillin (AMX); S2 is a variant of S1 combined with S49B4 bioactive glass (BG); and S3 is a variant of S1 combined with surface-functionalized S49B4 bioactive glass (SFBG). Optimizing the electrospinning procedure allowed for producing membranes with diameters ranging from 110 to 550 nm. Using a range of characterization techniques, the structure and morphology of the membrane, wettability, biodegradability, bioactivity, phase change, thermal properties, functional groups, mechanical properties, and drug release kinetics were all investigated. The inclusion of BG, SFBG, PVP, and AMX altered the properties of PCL. The hydrophilicity of the composite membrane also significantly increased. S1 displayed surface degradation in the bioactivity investigation of the samples in SBF, but adding BG (S2) and SFBG (S3) enhanced fiber integrity and encouraged hydroxyapatite formation. Notably, S1 showed significant ductility, while the addition of BG and SFBG in S2 and S3 increased the mechanical strength, although with a compromise in elasticity. S3 showed the highest drug-loading capacity, measuring 95.8 ± 0.8%, compared to S1 and S2. Zero-order, Higuchi, Kosmeyer-Peppas (K-P), and Peppas-Sahlin (P-S) kinetic models were used to fit the drug release data for all fibers; K-P fit S1 the best, while P-S fit S2 and S3. The results demonstrated that class II relaxations and Fickian diffusion controlled the drug transport mechanism. The release curves showed a faster phase that lasted up to 63 days, followed by a slower burst release with an average release value of 46% within the first 24 h. Thus, our work provides important insights into the properties and drug release capabilities of the composite S1–S3 membranes, suggesting their potential use in biomedical and tissue engineering applications.