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<p>For several decades, piezoelectric barium titanate (BT), hydroxyapatite (HA), and their hybrid composites&#xa0;have been used to serve diverse applications in&#xa0;biomedical field. These composites have advantages comprising bio-inertness, osteoconductivity, high compressive strength, biocompatibility, and biodegradability, rendering them suitable candidates for dentistry and orthopaedic applications. This study aims to develop a modified implantable bone filler composite, i.e., lanthanum-substituted hydroxyapatite—barium strontium titanate (LaHA-BST, 60:40 weight ratio), to imitate the electrical characteristics of natural bone. 10%LaHA-10%BST and 10%LaHA-20%BST composite specimens were synthesized using conventional wet precipitation and solid-state methods. It was observed from the thermally stimulated depolarization current (TSDC) measurement that, at a polarizing temperature of 493&#xa0;°C, the negatively poled 10%LaHA-20%BST composite exhibited a peak current density of 4.44&#xa0;nA/cm<sup>2</sup>, which results in improved osteogenesis. Also, the inclusion of greater concentrations of Sr promoted cell proliferation and viability, as well as enhanced osteogenic gene expressions. Controlled release of La<sup>3+</sup> from the composite specimens enhanced the antimicrobial behaviour of the specimen. Our in vitro results reflect that LaHA-BST has relevant applications in bone tissue regeneration therapies.</p>

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Electrically Polarized La-Substituted HA-BST Composite Shows Enhanced Osteoblast Activities and Inhibits S. aureus Bacteria

  • 期刊论文

  • 发表日期：

    2025年1月27日

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  • Rojaleen Lenka,
  • Subhasmita Swain,
  • Tapash R. Rautray

摘要

For several decades, piezoelectric barium titanate (BT), hydroxyapatite (HA), and their hybrid composites have been used to serve diverse applications in biomedical field. These composites have advantages comprising bio-inertness, osteoconductivity, high compressive strength, biocompatibility, and biodegradability, rendering them suitable candidates for dentistry and orthopaedic applications. This study aims to develop a modified implantable bone filler composite, i.e., lanthanum-substituted hydroxyapatite—barium strontium titanate (LaHA-BST, 60:40 weight ratio), to imitate the electrical characteristics of natural bone. 10%LaHA-10%BST and 10%LaHA-20%BST composite specimens were synthesized using conventional wet precipitation and solid-state methods. It was observed from the thermally stimulated depolarization current (TSDC) measurement that, at a polarizing temperature of 493 °C, the negatively poled 10%LaHA-20%BST composite exhibited a peak current density of 4.44 nA/cm2, which results in improved osteogenesis. Also, the inclusion of greater concentrations of Sr promoted cell proliferation and viability, as well as enhanced osteogenic gene expressions. Controlled release of La3+ from the composite specimens enhanced the antimicrobial behaviour of the specimen. Our in vitro results reflect that LaHA-BST has relevant applications in bone tissue regeneration therapies.