Abstract <p>Addressing the growing complexities of natural resource degradation requires a transition from sustainability toward regeneration, wherein socio-ecological systems not only reduce harm but actively restore ecological integrity, social well-being, and institutional resilience. This paper proposes a Regenerative Resource Governance (RRG) framework that is grounded in occupational and environmental safety assurance, circular resource management, and community-led restoration within regenerative governance systems. Drawing insights from diverse natural resource sectors, the study positions resource managers as critical intermediaries linking local practices, community institutions, and global regulatory frameworks. The framework advances existing sustainable and circular approaches by embedding safety, technological adaptability, ethical stewardship, and participatory governance within regenerative transitions. By explicitly connecting ecological restoration with livelihood resilience, inclusive decision-making, and institutional capacity building, the RRG framework contributes to socially grounded and operationally adaptive governance pathways. The framework aligns with the United Nations Sustainable Development Goals (SDGs 6, 8, 12, and 15), offering policy-relevant guidance for integrating environmental integrity, decent work, and responsible resource use. The applicability of the framework is illustrated through the Chilika Lagoon system in India, where fisheries, tourism, and biodiversity conservation intersect within a multi-stakeholder governance context, demonstrating how regenerative resource governance can support ecosystem renewal alongside long-term socio-ecological well-being.</p> Clinical manuscript trial number <p>Not Applicable</p> Graphical Abstract <p></p>